{"product_id":"dao-enzyme-1","title":"DAO Enzyme","description":"\u003ch5\u003eOrtho Molecular DAO Enzyme\u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp\u003e\u003cem\u003e30,000 HDU | Gastrointestinal Health \u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDAO Enzyme contains a purified form of diamine oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine in the gut before it enters systemic circulation. By supporting histamine degradation at the intestinal barrier, DAO Enzyme helps to alleviate histamine reactions from dietary triggers. This formula is highly concentrated, delivering 30,000 Histamine Degrading Units (HDUs) per capsule for effective histamine balance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eHistamine is a biogenic amine derived from histidine, and functions as a neurotransmitter, immune mediator, and local signaling molecule. It interacts with various receptors (H1–H4), leading to effects like vasodilation, inflammation, smooth muscle contraction, and sensory nerve stimulation. Histamine is present within most bodily tissues and can be synthesized in large amounts by white blood cells.\u003c\/p\u003e\n\u003cp\u003eHistamine is not only produced in the body but is present in a wide range of foods produced by bacteria that decarboxylate histidine into histamine. Foods prone to high histamine content include aged or fermented products and refrigerated leftovers. Specifically, matured cheeses, cured or processed meats, fish, and fermented beverages like beer and wine commonly contain elevated histamine levels. Histamine overload may occur after consuming foods with a high histamine content that overwhelms endogenous degradation mechanisms. Even lower histamine amounts found in common food servings can provoke symptoms in sensitive individuals with compromised DAO activity or histaminergic food reactions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eKey Benefits and Features: \u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eSupports healthy DAO enzyme activity in the digestive tract\u003c\/li\u003e\n\u003cli\u003ePromotes balanced histamine levels in response to dietary triggers\u003cspan\u003e\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ctable width=\"100%\" style=\"width: 100%;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 96.9314%;\"\u003e\u003cstrong\u003eServing Size: 1 Capsule\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 2.70758%;\"\u003e\u003cstrong\u003eAmount\/Serving\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 96.9314%;\"\u003ePorcine Kidney Extract (DAOgest) (providing 30,000 HDU Diamine Oxidase (DAO))\u003c\/td\u003e\n\u003ctd style=\"width: 2.70758%;\"\u003e4.2 mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003eOther Ingredients: \u003c\/strong\u003eMicrocrystalline Cellulose, Delayed Release Capsule (Hypromellose, Gellan Gum), Magnesium Stearate, and Silicon Dioxide. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDoes Not Contain: \u003c\/strong\u003eGluten, corn, yeast, artificial colors, or flavors. \u003c\/p\u003e\n\u003ch3\u003eSuggested Use\u003c\/h3\u003e\n\u003cp\u003eTake 1 capsule 15 minutes before a meal or as recommended by your healthcare professional. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWarning:\u003c\/strong\u003e If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Keep tightly closed in a cool, dry place. \u003c\/p\u003e\n\u003ch3\u003eMore Info. \u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eDAO and Histamine Degradation\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eHistamine, both endogenously synthesized and ingested through diet, can be metabolized through two pathways: methylation by histamine N-methyltransferase (HNMT) and degradation by DAO. DAO is responsible for the degradation of histamine-containing foods. Highly expressed in the intestinal mucosa, it is most active in the small intestine and is also present in the colon, kidneys, thymus, and placenta. Released into the intestinal lumen, DAO serves as a crucial protective barrier that metabolizes dietary histamine before it can be absorbed into the bloodstream.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eVariability in Histamine Tolerance\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eInterindividual tolerance of dietary histamine is highly variable. A disruption in the balance between histamine accumulation and DAO activity has been associated with manifestations affecting the gastrointestinal tract, skin, and respiratory mucosa. Studies have shown that the degree of DAO impairment often correlates with the integrity of the intestinal barrier, leading to the proposal that DAO activity can serve as a marker of intestinal mucosal integrity. Additionally, genetic and environmental factors appear to interact in modulating DAO expression and activity; more than 50 polymorphisms in the gene encoding DAO have been identified that lead to impaired enzyme activity.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eClinical Studies\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eIn a four-week, open-label study of 28 adults with histamine intolerance, oral DAO capsules were associated with an improvement in all 22 histamine intolerance symptoms. In the subsequent withdrawal phase, symptom scores rose again, returning toward pre-treatment levels and further supporting DAO’s effects.\u003c\/p\u003e\n\u003cp\u003eHistamine has been implicated as a trigger for neurological discomfort in some individuals. A one-month, double-blind, placebo-controlled trial investigated DAO supplementation as a preventive therapy for histamine-related neurological discomfort in 100 participants with documented DAO deficiency—the DAO-treated group experienced a 1.4-hour reduction in the duration of symptoms with no adverse effects reported.\u003c\/p\u003e","brand":"Ortho Molecular","offers":[{"title":"60 Capsules","offer_id":43967250792535,"sku":"ORT-178060","price":57.2,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0193\/9503\/files\/DAO_Enzyme_Front-removebg-preview_1.png?v=1781816496","url":"https:\/\/www.healthyhabitsliving.com\/products\/dao-enzyme-1","provider":"Healthy Habits Living","version":"1.0","type":"link"}