Folic acid plays a large role in the reduction of homocysteine.
For many seeking high doses of folic acid, a folic acid supplement containing 5 mg has been previously available only through prescription, even though Folic Acid has never been a pharmacy-only ingredient. A required component for the conversion of homocysteine to methionine, folic acid supplementation reduces homocysteine levels as demonstrated in many clinical studies. Regardless of initial homocysteine levels, increased folic acid supplementation (up to 800 mcg) has been shown in research to enhance an increased homocysteine lowering effect. Those with higher initial homocysteine levels had greater lowering effects with folic acid. Low levels of daily folic acid intake have been associated with high serum homocysteine levels, especially in the elderly. Current research is showing that aggressive homocysteine management is more beneficial than previously thought.