Douglas Laboratories Methylated Resveratrol Plus
Methylated Resveratrol Plus provides pterostilbene, a methylated resveratrol that occurs naturally in berries. This formula also contains resveratrol, curcumin and vitamin D3 , which compliment pterostilbene in supporting metabolic health. Ptersotilbene targets PPAR alpha, which plays important roles in lipid metabolism. Reserveratrol supports mitochondrial function by promoting the actions of SIRT1, a cellular enzyme that contributes to healthy aging.
Each serving contains:
Vitamin D3 (Cholecalciferol) - 1,000 IU
Meriva® Curcumin Phytosome - 250 mg
(Curcuma longa extract, rhizome/Phosphatidylcholine (soy) complex)
Resveratrol (as resVida® trans-resveratrol) - 100 mg
Pterostilbene (methylated resveratrol, pTeroPure®) - 50 mg
Proprietary Cruciferous Vegetable and Fruit Blend - 150 mg
Wasabia japonica (rhizome), Broccoli powder (sprout)
(standardized to contain 200 mcg of sulforaphane) and Organic Pomegranate powder (fruit).
Other ingredients: Hydroxypropyl methylcellulose (capsule), calcium citrate, microcrystalline cellulose, vegetable stearate, silica and titanium dioxide.
resVida® is a registered trademark of DSM.
pTeroPure® is a trademark of ChromaDex, Inc.
Meriva® is a registered trademark of Indena S.p.A, Milano.
As a dietary supplement, adults take 1 capsule daily or as directed by your healthcare professional.
Pterostilbene, a methylated form of resveratrol is considered the next generation of resveratrol. Pterostilbene has advantages over resveratrol: superior biological activity, better oral bioavailability, and slower metabolism in the body. pTeroPure ™ pterostilbene is a nature identical form of trans-pterostilbene, a stilbene found in certain berries. The enhanced activity of pterostilbene compared to resveratrol may, in part, be explained by structural differences. Pterostilbene with two methoxy groups and one hydroxyl group has greater lipophilicity and a higher potential for cellular uptake than resveratrol, which has three hydroxyl groups. Pterostilbene showed strong inhibitory activity, much more than resveratrol, against a particular form of cytochrome P450. Researchers have suggested that these two compounds also work synergistically, supporting the theory that a combination of pterostilbene and resveratrol in a formulation may be more effective than using these ingredients separately.
Both pterostilbene and resveratrol support mitochondrial function and healthy aging by activating SIRT1, one of the key enzymes of the sirtuin family. Sirtuins, a class of proteins, have been implicated in influencing aging and regulating transcription, apoptosis and stress resistance, as well as energy efficiency and alertness during low-calorie situations. Pterostilbene also supports cardiovascular health; results from in vitro studies showed that pterostilbene acts as a PPARR agonist and may be a more effective PPARR agonist and hypolipidemic agent than resveratrol. In vivo studies demonstrate that pterostilbene supports glucose metabolism. This product also contains Resvida ™, a pure resveratrol clinically studied for its safety. Resvida ™ resveratrol is unique as it is not a plant extract and is not derived from plant sources, therefore presents no risk for contamination with pesticides and other potentially unwanted compounds. Studies indicate resveratrol may be supportive in maintaining the normal aging process by helping to prevent free radical damage that can lead to premature aging of cells.