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Boluoke: The Enzyme for Circulation

by Carly Neubert, BA, NC on September 11, 2019

Boluoke is a strange-sounding and looking word. It is the name of the clinically studied lumbrokinase enzyme supplement made by Canada RNA. You might think that you can just go to the vitamin store, pick up a lumbrokinase enzyme supplement and you will be getting the same benefits as taking Boluoke. Unfortunately, you would be incorrect.

Boluoke is a highly concentrated and medically studied lumbrokinase extract. It is the only medically studied earthworm supplement. Like many of the products I recommend, Boluoke is superior to all the competing lumbrokinase enzyme supplements that are available.

Canada RNA manufactures a 90 count and 120 count bottle of Boluoke lumbrokinase supplements. The 120 count bottle is useful because most recommendations include a titration dosage.

What is Lumbrokinase?

Lumbrokinase is an enzyme that is also known as a fibrinolytic and proteolytic enzyme. It is often compared to serrapeptase and nattokinase, which are also proteolytic enzymes. However, neither nattokinase nor serrapeptase has been studied as rigorously as lumbrokinase. All three are considered fibrinolytic enzymes which dissolve fibrin, the protein in your blood that creates clots; you can think of fibrin as a sort of internal scab.

Generally, a clot, just like an external scab, is trying to healing something. All three enzymes will dissolve fibrin, but Bolouke lumbrokinase has proven to work faster and more efficiently.

The history of Boluoke?

Traditional Chinese Medicine (TCM) practitioners have been making tea from earthworms for centuries. The newer version of this treatment is a tea made from powdered earthworm extract.

Until the 1980s, scientists had not yet determined which part of the earthworm (Lumbricus rubellus) extract was helpful for circulation, so the entire earthworm extract was used as a treatment. Can you imagine drinking a tea made of mashed up earthworms?

Then in 1980, Dr. Hisashi Mihara and his team successfully isolated the exact proteolytic enzymes in earthworm powder. They discovered that the enzyme lumbrokinase was actually a few proteolytic sub-enzymes that are now collectively called lumbrokinase.  

Boluoke is not a capsule filled with ground-up earthworms. It is the purified lumbrokinase enzyme extract from earthworms. Boluoke is the only lumbrokinase that contains only pure enzymes. All other lumbrokinase supplements contain a small amount of lumbrokinase, mixed with various proteolytic enzymes and earthworm proteins. In essence, they are “watered-down” or “cut” with bulk earthworm powder that does not have proteolytic (anti-fibrin) properties.

Boluoke vs Nattokinase

If you are comparing Boluoke versus (vs) Nattokinase, 2 capsules of Boluoke are more potent than 20 capsules of Nattokinase. Nattokinase is another fibrin-eating enzyme. It is derived from fermented soybeans.  

In a comparison study, Boluoke showed 300 times the strength as a similar dose of serrapeptase. Serrapeptase is another proteolytic enzyme that is derived from a worm. In this case, the enzymes are extracted from silkworms.  

While both serrapeptase and nattokinase are proteolytic enzymes, they have not proven to have the strength of unadulterated lumbrokinase enzyme in Boluoke.


Does Boluoke Really Work?

I have personal experience with Boluoke, so here's my story:
I had heard and read that people with Chronic Fatigue Syndrome, Lyme disease and other immune/inflammatory disorders have “thick blood,” but I had not explored that in my own body.

So, a few years ago, when I developed a sheath clot from my elbow to my clavicle and then a week later I got a shorter clot in my other arm I took Coumadin and tried to find the thereuptic dose for 4 weeks, as directed by my doctor. I even stopped eating dark leafy greens because of the interaction that they can have with blood thinning medications like Coumadin. I also started taking high dose fish oil, nattokinase, and vitamin E.

After 4 weeks I had a follow-up ultrasound to see if the clots have dissolved or moved...  


Nothing had happened. I was so frustrated because I was sick of changing doses of Coumadin and having my blood checked 3 times per week via the veins in my hands. OUCH!!! So, I started taking Boluoke at the highest dose recommended even though Boluoke is fairly expensive and I didn’t know very much about it. I didn’t feel any different and I still had some swelling in my arm with the sheath clot.  

But sure enough, later when I went for a follow up ultrasound….. No clots. No residual. Nothing. I was able to go off Coumadin with the help of my doctor and I start eating dark leafy greens immediately!
Well worth it!

When Should You Use Boluoke?

Not only is it useful for a DVT, but it is more commonly used for hypercoagulability and bacterial biofilms. Boluoke seemed to be a well-kept secret until a few years ago. Boluoke lumbrokinase has received a lot of attention from integrative medical doctors, especially those who treat Lyme, CIRS, and other complex illnesses.

These illnesses often include biofilms and hypercoagulation. A Lyme disease infection often seems to be immune to antibiotics and antimicrobial agents. This is due to the biofilms or protective coatings that accumulate around the bacterial colonies. Boluoke enzymes break through the biofilm which allows antimicrobial herbs to kill the Lyme disease spirochete.


Why should I choose Canada RNA Boluoke (Lumbrokinase)?

All of the competing products are likely just earthworm protein extract containing very little pure lumbrokinase enzymatic strength. Unfortunately, some companies are making products with 230mg to 250mg of lumbrokinase per capsule and then quote research that was conducted using Bolouke concentrated lumbrokinase enzymes. Boluoke capsules are of 200mg in size, and contain 20mg of lumbrokinase inside each capsule. Other lumborkinase products are unable to measure a standard enzyme strength in their capsules.

In plain English: When you buy other lumbrokinase products, you are NOT assured a specific dose of the enzyme. You are basically getting an earthworm protein and enzyme stew. The enzyme portion could be high or low. Boluoke guarantees that you are getting 20mg of active enzyme per capsule.

Boluoke is an enzyme and should not be taken at the same time as other enzyme supplements. Boluoke may be rendered ineffective by the action of other enzymes. Boluoke comes in an enteric-coated capsule. This ensures that most of the enzymes survive your stomach acid.

If you find capsules difficult to swallow, you may open the capsule. However, not all of the active enzymes will make it past your stomach acid. A higher dose may be necessary.

Boluoke, like all proteolytic enzymes, can be a powerful way to detoxify from infections or heavy metal toxicity. Start slowly and always use a binder in conjunction with Boluoke. A binder is a supplement like charcoal, clay, psyllium, etc. These supplements bind to toxins in the body so that they can pass through the digestive tract and be eliminated. Takesumi Supreme is a good choice.

 Week 1

1 cap on empty stomach
 Monday, Wed, Friday

Followed by a binder 30 minutes later 

Week 2

1 cap on empty stomach       Monday-Friday

Followed by a binder 30 minutes later

Week 3

1 cap on empty stomach       Monday-Sunday

Followed by a binder 30 minutes later

One capsule per day is a good general maintenance dose. If you are dealing with Lyme or other biofilms or heavy metals, please schedule a consult with me to create a personalized program for you.

Here is to your empowered health!


Carly Neubert BA, NC


For additional recipes, biohacking tips and lifestyle hacks -- check out my other blog on my coaching site www.cleancoachcarly.com! I post weekly about nutrition and lifestyle topics, all backed by science. Happy Reading!


Lumbrokinase References
Bolouke Introduction
Boluoke comparisons