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Bacteria often grow within biofilm, a slimy coating that adheres to living tissues. Biofilm is a thick and sticky substance comprising proteins, polysaccharides and other biomaterials along with divalent cations. This self-made matrix surrounds and shields the microbes from exposure to immune cells and antimicrobial molecules. Biofilm complexes are notoriously difficult to disrupt.
Biofilm Neutralizer comprises two orally-available enzymes, trypsin and serrapeptidase, along with alpha-lipoic acid and EDTA (ethylenediaminetetraacetic acid), in a delayed-release capsule (DRCaps®). This mixture is designed to disrupt the bonds that hold biofilm together.
| Serving Size: 1 Vegetarian Capsule | Amount/Serving |
| Calcium (from 100 mg of EDTA Calcium Disodium salt) | 6 mg |
| Sodium (from 100 mg of EDTA Calcium Disodium salt) | 9 mg |
| Alpha Lipoic Acid | 150 mg |
| Trypsin 1:150 Powder (containing at least 15,000 units of protease) | 50 mg |
| Serrapeptidase 70,000 SPU | 35 mg |
Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, stearic acid, silicon dioxide.
DRcaps® is a trademark of Lonza or its affiliates.
As a dietary supplement, 1 capsule one or two times daily between meals, or as directed by a healthcare practitioner.
Warning: EDTA is known to deplete minerals, so repletion is suggested. Higher doses or long-term use require the guidance of a qualified healthcare practitioner with ongoing monitoring of liver and kidney function.
Keep in a cool, dry place, tightly capped.
Serrapeptidase (serratiopeptidase) is a proteolytic enzyme produced by Serratia, a microbe that lives in the digestive tract of various species. Originally isolated from the silk worm, serrapeptidase allows the emerging moth to dissolve its cocoon. Purified serrapeptidase has been shown to break down biofilm-associated proteins without harming human tissues. Serrapeptidase is orally available, and it has systemic fibrinolytic effects.
Trypsin is a proteolytic enzyme made by the pancreas. It digests a wide range of substrates including bacterial proteins. Trypsin has been shown to reduce the viscosity and permeability of the biofilm matrix, and to loosen the attachment of biofilm to living tissues. Additionally, trypsin removes bacterial surface proteins. Supplemental trypsin is orally available, with the active enzyme appearing in the bloodstream shortly after ingestion.
Alpha-lipoic acid (ALA) is a potent antioxidant found in plants and animals. Low antioxidant capacity leads to oxidative stress, which triggers microorganisms to shift to a biofilm-producing state. In clinical trials, ALA has been shown to improve total antioxidant capacity by increasing glutathione, the master antioxidant within cells. Adequate glutathione levels are associated with healthy immune function. Additionally, both ALA and glutathione have direct biofilm-disrupting effects.
EDTA Calcium Disodium Salt: EDTA (ethylenediaminetetraacetic acid) is a chelator that binds divalent cations. Oral EDTA formulations are sometimes used to remove heavy metals, such as lead, from the body. EDTA loosens the bonds between calcium and alginate, a polysaccharide that strengthens the biofilm matrix. The addition of EDTA enhances the penetration of antimicrobial molecules into biofilm complexes. The calcium disodium form of EDTA is preferred because it protects serum calcium levels.
