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Nrf2 Activator for Antioxidant and Detoxification Support
Cytokine Balance is an exclusive formula designed to activate the Nrf2 genetic pathway. This pathway regulates the production of important molecules that impart antioxidant activity, such as glutathione and superoxide dismutase (SOD). It also regulates the production of detoxification enzymes, including glutathione S-transferase, and downregulates signaling factors such as NF-κB.
| Serving Size: 2 Capsules | Amount/Serving |
|---|---|
|
Turmeric Extract (Curcuma longa)(rhizome)(95% total curcuminoids complex, including curcumin, curcuminoids, and volatile oils)(86% curcuminoids)(65% curcumin)S1 |
400 mg |
| 400 mg | |
|
trans-PterostilbeneS2 |
100 mg |
|
Glucoraphanin (from broccoli extract)(Brassica oleracea italica)(seed)S3 |
60 mg |
Other Ingredients: Capsule (hypromellose and water), stearic acid, magnesium stearate, and silica.
Does not contain: Wheat, gluten, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
Take one to two capsules daily, or as directed by your healthcare practitioner.
Consult your healthcare professional prior to use. Individuals taking blood thinners or other medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.
Keep tightly closed in a cool, dry place out of reach of children.
Nrf2 (NF-E2-related factor 2), a transcription factor in humans that is encoded by the NFE2L2 gene, regulates the expression of a set of antioxidant and detoxifying genes. Nrf2 is intricately involved in inhibiting proinflammatory cytokines, the chemical messengers communicating with cells and coordinating immune responses. In an unstressed state, Nrf2 is anchored in the cytoplasm by its specific inhibitor Keap1 (kelch like ECH-associated protein 1). Keap1 functions as a sensor for oxidants and electrophilic xenobiotics. In the presence of any of these substances, Keap1 gives up its inhibition of Nrf2. This action stabilizes Nrf2, allowing it to accumulate in the nucleus and bind to the antioxidant response element (ARE) located in the enhancers of its target genes. Under this circumstance, Nrf2 then upregulates a variety of antioxidant enzymes and detoxifying proteins.
