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Ortho Molecular
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Women's HealthÂ
Femarin is a unique blend of botanicals formulated to provide targeted support for a comfortable and balanced menopausal transition.
The cessation of a woman’s menstrual cycle typically occurs in midlife, during the late 40s or early 50s, and signals the end of the fertile phase. For some women, the accompanying signs and effects that can occur during the transition years can be strong enough to significantly disrupt daily activities and sense of wellbeing. Femarin contains five key ingredients, each of which plays a role in supporting a woman’s unique needs during this period. Specifically, Femarin’s formula addresses hormonal balance, maintains normal inflammatory balance, and provides antioxidant support, as well as cardiovascular and bone support for a full spectrum of protection and menopausal symptom relief.
Key Benefits and Features:Â
| Serving Size: 2 Capsules | Amount/Serving |
| Gamma Oryzanol | 300 mg |
| Black Cohosh Root Extract (Standardized to contain 2.5% Triterpene Glycosides)Â | 160 mg |
| Dong Quai Root Extract (Standardized to contain 1% Ligustilide)Â | 75 mg |
| trans-Resveratrol (from Polygonum cuspidatum (Roots)) | 4 mg |
Other Ingredients: Natural Vegetable Capsules, Microcrystalline Cellulose, and Magnesium Stearate.Â
Does Not Contain: Gluten, yeast, artificial colors, or flavors.Â
Take 2 capsules per day in divided doses or as recommended by your health care professional.
Warning: Do not consume this product if you are pregnant or nursing. Consult your physician for further information. Keep out of the reach of children.Â
Storage: Keep tightly closed in a cool, dry place.Â
Black Cohosh Root Extract
Black cohosh root extract has been extensively studied for its hormone-balancing benefits during perimenopause and menopause. Â In fact, this botanical has been widely used for more than 40 years in Europe and is approved in Germany for premenstrual discomfort and menopausal symptoms. Black cohosh root contains triterpene glycosides, such as cimicifuoside and actein, and phenolic compounds thought to contribute to its therapeutic effects, particularly in relation to menopause. Black cohosh has been shown to significantly reduce menopause-related symptoms, even when compared to other regimens in double-blind, placebo-controlled studies.
In an open-label trial of 629 patients with menopausal complaints given black cohosh, 80% of the patients improved after four weeks, and within a six-to eight-week period, 50% reported a complete disappearance of symptoms. Studies have also shown that black cohosh supports emotional well-being by promoting a sense of calmness, along with a positive mental outlook. The literature shows that black cohosh is beneficial to vaginal superficial cells and bone health without causing effects on the endometrium or follicle-stimulating hormone (FSH) levels. While it is not a phytoestrogen, black cohosh may act via serotonergic pathways, antioxidant activity, and modulation of estrogen receptors.
Trans-Resveratrol
Resveratrol, a polyphenol found in grapes and red wine, has been shown to have an effect on free radical scavenging and antioxidant properties in various tissues. Similar in structure to estrogen, trans-resveratrol provides a range of supportive activities, including hormonal balance and maintaining normal inflammatory balance. Resveratrol can support bone health by regulating the metabolism of bone cells and modulating bone turnover.10 Resveratrol also supports cardiovascular health by protecting lipids from peroxidative degradation and preventing the uptake of oxidized LDLs in the vascular wall. Grape polyphenol supplementation was found to significantly reduce whole-body oxidative stress and also decrease the levels of plasma tumor necrosis factor-alpha, a key inflammatory marker.
Licorice Root ExtractÂ
Licorice root is a botanical used medicinally in both Western and Eastern cultures for several thousand years, and is widely used today in Chinese medicine. The active component glycyrrhizin is well-known for its ability to prolong the half-life of cortisol, supporting the body’s stress response. Licorice also contains flavonoids, such as glabridin, which have weak phytoestrogenic effects that may help balance estrogen levels, particularly in cases of estrogen dominance. Studies have shown that glycyrrhizin can bind to both estrogen and androgen receptors.Â
In addition, licorice has also been shown to support healthy bone mineral density in postmenopausal women and to inhibit serotonin reuptake, which is essential for supporting a healthy mental outlook.
Gamma Oryzanol
Gamma oryzanol (ferulic acid) is a natural compound extracted from rice bran oil. Gamma oryzanol was first shown to be effective for relieving hot flashes in the early 1960s. Numerous studies have highlighted the benefits of gamma oryzanol for menopausal complaints. An initial study found that 300 mg/ day of gamma oryzanol over 38 days was able to reduce, by half, menopausal symptoms in 67% of the women studied. A more recent study of 40 women given a dose of 300 mg/ day of gamma oryzanol showed a reduction in menopausal symptoms in 85% of female subjects. In addition to helping with symptoms of menopause, gamma oryzanol has also been shown to be effective in maintaining healthy cholesterol and triglyceride levels.
Dong Quai
Considered by many as the woman’s herb, Dong quai (Angelica sinensis) is native to China and Korea, where it is considered as a “female ginseng” due to its ability to support a regular and healthy menstrual cycle, and reduce menopausal symptoms, including hot flashes. While the roots contain coumarins, flavonoids, and essential oils, its beneficial effects are more likely due to its normal inflammatory balance support and circulatory-enhancing properties rather than direct phytoestrogen activity. Dong quai works most optimally when in synergy with other botanicals to support menstrual regularity and help nourish dry and thin vaginal tissues from menopause.
