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5-methyltetrahydrofolic acid, Glucosamine salt
XaQuil® XR is an orally administered medical food* for use only under the supervision of a physician for the metabolic management of low 5-methyltetrahydrofolic acid (5-MTHF) levels associated with depression.
Key Benefits:
| Serving Size: 1 Tablet | Amount/Serving |
|
Folate (as (6s)-5-methyletrahydrofolic acid, glucosamine salt) |
25,500 mcg DFE |
Other Ingredients: Dicalcium phosphate, microcrystalline cellulose, coating (talc, shellac, vegetable glycerin, L-arginine, vegetable magnesium stearate, silica, sodium alginate, titanium dioxide, riboflavin 5'-phosphate sodium), vegetable stearic acid, ([6S]-5 methyltetrahydrofolic acid, glucosamine salt), vegetable magnesium stearate, and croscarmellose sodium.
Take one tablet daily with or without food, or as directed by your physician.
Warning: For use under the supervision of a physician. Keep this and all medications out of the reach of children.
Storage: Keep closed in a cool, dry place out of reach of children.
XaQuil®XR provides Quatrefolic®, a patented glucosamine salt of (6S)-5-methyltetrahydrofolate. Quatrefolic is a proprietary and biologically active form of folate, also known as vitamin B9. Folic acid and dietary folate are converted by the methylenetetrahydrofolate reductase (MTHFR) enzyme to 5-methyltetrahydrofolate (5-MTHF), the biologically active form of folate in the body. Supplementation of folate in the form of Quatrefolic bypasses the need for conversion by the MTHFR enzyme as it delivers the 5-MTHF molecule in its biologically active form. This can help overcome the challenges of improving folate status in individuals with certain genetic polymorphisms.
MTHFR Polymorphism
The MTHFR enzyme is necessary for converting folic acid and dietary folate to 5-MTHF. The bioactive form of folate, 5-MTHF, plays a key role in the manufacture of S-adenosylmethionine (SAMe); methylation of DNA, proteins, neurotransmitters, and phospholipids; and methylation of homocysteine to methionine.1-4 Nutrigenomic research indicates that because of their unique genetic patterns and expression, some individuals do not produce adequate or effective MTHFR.
Research has shown Quatrefolic to be 7 times more bioavailable than folic acid. In other research, Quatrefolic was more effective than folic acid at increasing total plasma folate
concentrations in subjects with the TT and CC genotype of the 677C→T mutation of MTHFR.
Quatrefolic
Quatrefolic is a patented dietary ingredient that shows enhanced stability and bioavailability compared with the calcium salt form of L-5-methyltetrahydrofolate. In a direct comparison between Quatrefolic, L-5-methyltetrahydrofolate calcium salt, and folic acid in rats, Quatrefolic demonstrated a much higher absorption rate. The Quatrefolic arm
demonstrated a plasma concentration peak 1.8× higher than L-5-methyltetrahydrofolate calcium salt and 3.1× higher than folic acid. In a single-dose, balanced, 2-sequence,
2-period, 2-treatment, randomized, crossover human study, Quatrefolic showed better bioavailability (+10%) than L-5-methyltetrahydrofolate calcium salt.
5-MTHF and Depression
It is estimated that one-fourth of the US population will have a depressive episode sometime in their lives. There is a significant association between MTHFR polymorphism
and depression risk. 5-MTHF supports the biosynthesis of brain neurotransmitters like serotonin, norepinephrine, and dopamine. For example, 5-MTHF is required for the methylation of homocysteine to create methionine, and SAMe is the downstream metabolite of methionine. Without enough 5-MTHF, SAMe levels will decline. SAMe is involved in many biochemical methyl donation reactions, including the
formation of monoamine neurotransmitters. Researchers believe that inadequate 5-MTHF, whether due to folate deficiency or the inability to sufficiently convert dietary folate
and folic acid to 5-MTHF, impacts the complex balance of brain neurotransmitters. Supplementation with oral 5-MTHF has been reported as beneficial in depressive disorders.
Adjunctive Use of 5-MTHF in Major Depressive Disorder
Bioavailable forms of folate, like Quatrefolic in XaQuil XR, are indicated for the distinct nutritional requirements of individuals who have suboptimal 5-MTHF in their cerebrospinal fluid, plasma, and/or red blood cells. It is also indicated for those with major depressive disorder (MDD), with particular emphasis on adjunctive support for individuals who are on
an antidepressant. Bioavailable forms of folate are indicated in MDD, regardless of the MTHFR C677T polymorphism genotype.
It is important to note that folic acid, when administered in daily doses above 0.1 mg, may obscure the detection of B12 deficiency. The (6S)-5-methyltetrahydrofolic acid forms of folate, like Quatrefolic in XaQuil XR, do not mask B12 deficiency.
USP (United States Pharmacopeia) Dissolution Rate, USP-Grade Excipients
To support excellent quality and provide for the extended release of Quatrefolic, XaQuil XR has been designed to meet the criteria for the rate of dissolution and disintegration
according to USP 711 Dissolution, Method A for delayed-release dosage forms. In addition, the natural-source excipients used in XaQuil XR are USP grade, meaning they meet all of the specifications the USP establishes in its monograph for each ingredient.
Vegetarians
The glucosamine in Quatrefolic is animal and shellfish-free and is an excellent option for vegetarians.
