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Musculoskeletal Health
The ingredients in GABAnol promote muscle relaxation and relief of smooth muscle tension following exercise or strenuous activity.
GABAnol is a synergistic combination of gamma-aminobutyric acid (GABA), glycine, magnesium, vitamin B6, and dong quai, which serves as a quick response supplement for muscle relaxation and discomfort. The combination of glycine and GABA acts as an inhibitory neurotransmitters, which help calm muscles and reduce the activity of the excitatory nervous system that can cause muscle spasms.
GABA, the chief inhibitory neurotransmitter in the central nervous system, plays a key role in regulating muscle excitability. Both GABA and glycine act as calmatives for nerve impulses, controlling muscle contractions. GABA also supports the brain, preventing stress-related messages that trigger muscle spasms from reaching motor centers of the brain by occupying their receptor sites. While other therapies with a similar mechanism may cause dependency when used over time, the natural ingredients in GABAnol are non-habit forming and work quickly to ease muscle tension.
Key Benefits and Features:
| Serving Size: 2 Capsules | Amount/Serving |
| Vitamin C (as Ascorbic Acid USP) | 40 mg |
| Vitamin B6 (as Pyridoxine Hydrochloride USP) |
50 mg |
| Magnesium (as DiMagnesium Malate)(Albion®) |
100 mg |
| Gamma Aminobutyric Acid (GABA) | 250 mg |
| Glycine USP | 225 mg |
| Dong Quai Root Extract | 150 mg |
Other Ingredients: Microcrystalline Cellulose, Hypromellose (Natural Vegetable Capsules), Magnesium Stearate, Stearic Acid, and Silicon Dioxide.
Does Not Contain: Gluten, corn, yeast, artificial colors, or flavors.
Take 1-2 capsules three times per day or as recommended by your health care professional.
Warning: Do not consume this product if you are pregnant or nursing. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
GABA
GABA itself is the primary inhibitory neurotransmitter in the brain and regulates other neurotransmissions to prevent overstimulation. One study found that after only 60 minutes of administration, GABA significantly increased alpha brain waves and decreased beta waves compared to water or L-theanine, indicating a significant calming effect on the nervous system. The same study also found GABA to support healthy Ig levels. A randomized, single-blind, placebo-controlled, crossover-designed study found that among 63 adults given capsules containing 100 mg of GABA or a placebo, those who had taken GABA experienced diminished alpha band and beta band brain waves compared with the placebo.
Glycine
Glycine is one of three amino acids needed for the synthesis of creatine, which supplies energy to nerve and muscle cells. Elevated amounts of glycine are found in the muscles, skin, and other connective tissues. Glycine is also an inhibitory neurotransmitter, which works much like GABA. Research has shown that it supports the induction of sleep and enhances sleep quality. It is the primary amino acid that regulates neurotransmission in the brain stem and spinal cord and is a necessary cofactor in the activation of glutamate receptors. This action makes glycine a key component of maintaining nervous system balance and maintaining calm, relaxed muscles.
DongQuai
A perennial botanical native to China and Japan, dong quai is effective at easing post-exercise muscle soreness and has long been used medicinally for smooth muscle tension. Dong quai contains active ingredients called coumarins, which dilate blood vessels, balance the central nervous system, and increase blood flow. One animal study found dong quai to significantly increase endurance swimming time and to promote healthy blood sugar, lactate, ammonia, and creatine kinase levels in mice (a primary indicator of proper cellular energy function). Dong quai also improved exercise performance and eased exercise-induced fatigue in mice.
Vitamin B6
Vitamin B6 is required to convert glutamic acid to GABA in the body. Vitamin B6 is also a cofactor in many cellular biochemical reactions, including the release of glucose from glycogen and amino acid metabolism, including transamination, deamination, and decarboxylation. Vitamin B6 is involved in the electron transport system during ATP production and requires magnesium to become biologically active. The vitamin also supports the use of magnesium within the cell. It is a key factor in the methylation pathway, which is integral in many biochemical processes involving detoxification and cardiovascular, neurological, muscle, and bone health. Effective methylation plays a role in the biosynthesis and breakdown of catecholamines and is important in maintaining a positive mental outlook and supporting adrenal health.
Magnesium
Magnesium, the fourth most abundant mineral, participates in roughly 300-350 enzymatic reactions in the body. It aids in maintaining normal muscle and nerve function, blood pressure, heart rate, vasomotor tone, bone density, serum glucose levels, calcium absorption, and immune response. In a double-blind, between-group study, the effects of magnesium (350 mg/day for 10 days) on muscle soreness and performance in both college-aged males and females showed improved perceived recovery and a significant reduction in muscle soreness and perceived exertion.
Magnesium deficiency is one of the most common nutrient deficiencies that can lead to unwanted side effects when left untreated. In a prospective observational study, serum magnesium levels were measured between migraine and nonmigraine patients. The study concluded that those suffering from a migraine had relatively low serum magnesium levels in addition to a higher frequency of attacks compared to healthy controls, suggesting magnesium’s involvement in migraine pathogenesis. Another study involving patients diagnosed with fibromyalgia showed significantly lower levels of serum and erythrocyte magnesium levels compared to the control group. The study also showed a negative correlation between magnesium levels and fibromyalgia symptoms.
Because magnesium plays a significant role in regulating the influx of calcium into muscle cells, calcium can remain in the muscle cell for a longer period when magnesium is depleted, leading to cramping or muscle spasms. In a randomized, double-blind, placebo-controlled study, subjects suffering from nocturnal leg cramps received 226 mg of magnesium over a 60-day period. At the end of the study, subjects who were receiving the magnesium showed a significant decrease in the magnitude and duration of nocturnal leg cramps and improvements in sleep quality versus the placebo group.
