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Ortho Molecular
products.
Musculoskeletal Health
The Glucosamine Sulfate formula is a high-purity product that provides maximum support for joint health.
The joint cartilage is composed of collagen fibers, which impart tensile strength, and proteoglycan molecules (especially chondroitin and hyaluronic acid), which serve as a shock-absorbing cushion. The hands, as well as weight-bearing joints (knees, hips, and spine), are areas that undergo the greatest stress from the impacting pressure of weight and movement. In order to maintain joint health, it is important that the collagen matrix, or the support structure of the cartilage, remains intact. Glucosamine is an amino monosaccharide, which is a component of almost all human tissues, including cartilage. Glucosamine is the principal component of glycosaminoglycans (GAGs), which form the matrix of all connective tissues.
Glucosamine sulfate has a long history and an extensive body of research highlighting its role in protecting cartilage, the shock-absorbing, gel-like material located between the joints. As the key precursor to cartilage formation, glucosamine sulfate supports connective tissue health to provide full support for joint comfort, as well as integrity and movement, while maintaining normal inflammatory balance. Glucosamine sulfate is also a precursor to chondroitin sulfate and hyaluronic acid, both of which are natural compounds found in the synovial fluid of cartilage. The Glucosamine Sulfate formula provides maximum support for healthy joint function.
Key Benefits and Features:
| Serving Size: 1 Capsule | Amount/Serving |
| Potassium (as Glucosamine Sulfate Potassium Chloride USP) | 95 mg |
| Glucosamine Sulfate Potassium Chloride USP | 750 mg |
Other Ingredients: Hypromellose (Natural Vegetable Capsule), Microcrystalline Cellulose, Magnesium Stearate, and Stearic Acid.
Contains: Crustacean Shellfish (Shrimp and Crab).
Does Not Contain: Gluten, corn, yeast, artificial colors, or flavors.
Take as recommended by your healthcare professional.
Warning: If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
Joint Integrity and Movement
Glucosamine sulfate’s main physiological effect is to stimulate the production of glycosaminoglycans and promote the incorporation of sulfur into the cartilage, maintaining its gel-like structure and ability to act as a shock absorber. Glucosamine is the most fundamental building block for the biosynthesis of other compounds required to maintain joint health, including glycolipids, glycoproteins, hyaluronate, and proteoglycans. Meta-analyses have long confirmed positive findings for the use of glucosamine.
In an early double-blind, placebo-controlled trial of 80 subjects, half of the group received 1.5 g of glucosamine sulfate in 3 divided doses, and the other half was given a placebo. Those given glucosamine sulfate demonstrated a significant improvement in maintaining joint health versus the placebo group (71% vs. 41%). A more recent 16-week, randomized, double-blind, placebo-controlled trial assessed a glucosamine-based dietary supplement with chondroitin sulfate and three antioxidant micronutrients. It found that joint health was maintained at all four assessment time points (weeks 4, 8, 12, 16) in the control group, but not at any time point in the placebo group. Lastly, a 2013 study of data from a French database of 11,772 adults found that those taking a glucosamine supplement were able to maintain joint health.
Normal Inflammatory Balance
Although exact mechanisms of action are yet to be established, research suggests that glucosamine supplementation helps modulate cytokine production in addition to directly stimulating chondrocytes (cartilage cells that help produce and maintain a healthy cartilage matrix), while aiding in the incorporation of sulfur into cartilage.8,9 Glucosamine has been found to maintain normal inflammatory balance and alleviate oxidative stress.
