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Supports Glutathione Formation and Antioxidant Activity
Glutathione Precursors provide antioxidant support and support glutathione formation. Glutathione, or γ-glutamyl-cysteinylglycine (GSH), is the primary intracellular antioxidant involved in preventing lipid and protein oxidation, and is a critical component in the enzymatic process used to detoxify hydrogen peroxide (H2O2). Cysteine, glutamic acid, and glycine are the three essential precursors for endogenous glutathione production. Supplementation with NAC, cysteine, and glycine has been shown to increase GSH levels.
| Serving Size: 1 Capsule | Amount/Serving |
| N-Acetyl-L-Cysteine (NAC) | 200 mg |
| L-Glutamic Acid | 200 mg |
| DL-Alpha Lipoic Acid | 200 mg |
| L-Glycine | 100 mg |
Other Ingredients: Hypromellose and magnesium stearate.
Take one capsule daily with a meal or as recommended by your health professional.
Warning: If you are pregnant or lactating, have any health condition, or are taking any medication, consult your health professional before use. Keep out of the reach of children. Use only if the safety seal is intact.
Storage: Keep tightly closed in a cool, dry place.
GSH is considered an important free radical scavenger. In addition to its antioxidant effects, it also plays a key role in amino acid transport across membranes, gene regulation, and protein synthesis and degradation.7 GSH synthesis occurs primarily in the liver, following hepatic uptake of its precursors cysteine, glutamic acid, and glycine. As the intracellular pool of cysteine available for GSH formation is relatively small, cysteine is considered the rate-limiting factor for GSH production. Increased intake of cysteine (or its precursor NAC) has been shown to enhance GSH production. Conversely, oxidative stress and decreased protein intake are associated with reduced intracellular GSH concentrations.
Aging is associated with increased oxidative stress, and elderly people tend to have lower GSH levels and GSH synthesis rates in comparison with younger adults. In a 2-week-long clinical study conducted on healthy elderly participants, dietary supplementation with NAC and glycine restored GSH levels and synthesis rates comparable to measurements obtained from a younger adult control group. Participants received 0.81 mmol cysteine/kg/day (as n-acetylcysteine) and 1.33 mmol glycine/kg/day for 2 weeks.
At baseline and following supplementation, blood samples were obtained and analyzed to determine GSH synthesis rates in red blood cells, GSH levels, and plasma markers of antioxidant stress. In the elderly participants, GSH concentrations were approximately 46% lower, and the absolute synthesis rate of GSH was approximately 68% slower, in comparison with a group of healthy younger (30- 40-year-old) controls. Following supplementation, both GSH concentrations and GSH synthesis rates matched the control group, and plasma oxidant stress biomarkers (plasma reactive oxygen metabolites, plasma F2-isoprostanes, and lipid peroxides) were significantly decreased.
