Gluten Manager™ is a uniquely designed digestive enzyme that includes both endopeptidase and exopeptidase activity in the form of Tolerase® G and dipeptidyl-peptidase IV (also known as DPP-IV). The combination of activity causes degradation at both the ends as well as the middle of the gluten molecule. This makes a small gluten molecule proline peptide for easier and more complete digestion.
|Serving Size: 2 Capsules||Amount/Serving|
|Microbial Enzymes Proprietary Protease Blend providing
Tolerase® G Prolyl Endopeptidase 240,000 PPI
Dipeptidyl Peptidase (DPP-IV) Activity 100,000 HUT
Other Ingredients: hydroxypropyl methylcellulose (vegetable capsule), cellulose, calcium laurate, silicon dioxide
Take 1 or 2 capsules at the beginning of each meal or as recommended by your healthcare professional.
Avoiding dietary gluten can be a challenge. In a study of individuals with very high sensitivity to gluten that were following a gluten free diet, 66% suspected unintended exposure. Gluten can cause immunological and opioid-like effects on the nervous system of sensitive individuals. As gluten is a protein, it is typically broken down into small amino acids. However, gluten is comprised of gliadin which is difficult to digest due to the long proline peptides.
Gluten Manager has dual mechanism-of-action digestive enzymes that hydrolyzes gluten at both the middle and end of the gluten molecule through the use of prolyl-endopeptidase (Tolerase® G) and dipeptidyl-peptidase IV enzyme activity (DPP-IV). The use of both digestive enzymes degrades the proline peptide into smaller chains that can be more completely digested.
Theoretical mechanism of action using Tolerase G & DPP-IV
Caution: While Gluten Manager will reduce the level of reactive gliadin and gluten proteins in a meal, it is advised that celiac disease sufferers continue with their normal gluten exclusion diet as even small amounts of gliadin can cause adverse reactions in the most sensitized individuals. If pregnant, nursing or taking prescription drugs, consult your healthcare professional prior to use.
Tolerase® G is not intended to replace a gluten-free diet. Tolerase® G is not intended to treat or prevent celiac disease.
Tolerase® G is a trademark of DSM.