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HMF™ Forte is a unique combination of four strains of proprietary, human-sourced probiotics that help to promote gastrointestinal health in adults and children. Included in this blend are two strains of Lactobacilli acidophilus (CUL-60 & CUL-21), Bifidobacterium bifidum (CUL-20), and Bifidobacterium animalis subsp.lactis (CUL-34) to promote colonization in both the small and large intestines. Supplementation with large numbers of a combination of microorganisms will help maximize intestinal colonization, supporting the growth of beneficial bacteria.
Lactobacilli and Bifidobacterium, the most commonly used probiotics, help colonize the intestines and mediate the permeability of epithelial cells. In a double-blind, placebo-controlled study involving 138 adults, supplementation with the probiotic combination contained in HMF™ Forte was found to reduce the incidence of occasional diarrhea in adults taking antibiotics.
In addition, to this research-driven probiotic blend, HMF™ Forte also provides fructooligosaccharides (FOS), a prebiotic fiber to support the growth of beneficial bacteria in the intestines. This convenient shelf-stable format has guaranteed potency through expiration and may improve patient compliance.
| Serving Size: 1 Vegetarian Capsule | Amount/Serving |
| Probiotic Consortium | 10 billion CFU |
| Lactobacillus acidophilus (CUL-60 & CUL-21), Bifidobacterium animalis subsp.lactis (CUL-34) & Bifidobacterium bifidum (CUL-20) | |
| Fructooligosaccharides (FOS) | 100 mg |
Other Ingredients: Microcrystalline cellulose, hypromellose, silica, sunflower lecithin.
Dairy Free. Gluten Free. GMO Free. Soy Free. Vegan.
Take 1 capsule 2 times daily with meals or as recommended by your health professional.
WARNING: If you have an immune-compromised condition, do not use. If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use. If symptoms of digestive upset occur, stop use and consult your health professional. Keep out of the reach of children. This product was sealed for your protection. Do not use if box or contents are open or damaged.
Storage: Store in a cool, dry place.
Genestra HMF™ (Human Microflora) Probiotics offer:
HMF™ Forte is formulated using Genestra's proprietary Lactobaciilus and Bifidobacterium probiotic consortium - microorganisms that have been used in a wide body of clinical research. Studies demonstrate that these strains effectively maximize intestinal colonization to promote the growth of beneficial bacteria and support gastrointestinal comfort. In addition, these strains are selected based on their high quality, viability and strong epithelial adherence. They have also demonstrated naturally high tolerance to stomach and bile acid in preclinical research.
The human intestinal tract contains more than 400 bacterial species. This microflora composition can be altered by a number of factors., including diet, occasional stress, certain medications, aging and travel. When the microflora balance is affected in the intestines, common gastrointestinal complaints can occur, including mild bloating and gas.
Probiotics are defined by the World Health Organization as "live microorganisms which when administered in adequate amounts confer a health benefit on the host". Probiotics have been found to support gastrointestinal health and contribute to a healthy microflora composition. Studies have shown that they mediate microbial colonization and support the growth of beneficial bacteria in the intestines. Probiotics accomplish this by mediating intestinal pH and strengthening the epithelial barrier. They mediate the integrity of tight junctions and increase mucin release. which in turn regulates permeability and reduces microbial adherence to cells.
In one double-blind, placebo-controlled study involving 138 adults, participants were divided into two groups., receiving either a probiotic or placebo supplement for 20 days. Fecal samples were collected at the start of the trial and following antibiotic treatment. Each probiotic capsule was taken once-daily for 20 days and contained 2.0x10 CFU from a combination of Lactobacillus acidophilus (CUL-60 and CUL-21), Bifidobacterium animalis subsp.lactis (CUL-34), and Bifidobacterium bifidum (CUL-20). HMF Probiotic supplementation was found to reduce the incidence of occasional diarrhea following antibiotics.
HMF Probiotics were fond to modulate the intestinal microflora composition in another double-blind, placebo-controlled trial. Participants were divided into two groups, receiving either a probiotic or placebo supplement for 21 days. Fecal samples were collected at baseline (day one) and on days seven and 35 to determine the average bacterial composition. Each probiotic capsule was taken once daily and contained 2.5x10 CFU from a combination of two strains of Lactobacillus acidophilus (CUL-60 and CUL-21) and two strains of Bifidobacterium (Cul-20 & CUL-34). HMF Probiotic supplementation helped to support the growth of beneficial strains and maintain a healthy microflora balance.
In an eight-week long, double-blind, randomized, placebo-controlled study involving 52 adults, supplementation with a combination of four HMF Probiotic strains significantly reduced intestinal discomfort. Participants were randomized to either the placebo or probiotic capsule group (25 billion CFU from CUL-21, CUL-34 and CUL-20) and consumed one capsule daily for eight weeks. Participants scored their intestinal discomfort (including bloating, satisfaction with bowel habits and quality of life) at baseline and every two weeks during the supplementation period. When compared to baseline values, measures significantly improved after eight weeks of supplementation - including a 22% decrease in days with intestinal discomfort., 32% improvement in satisfaction with bowel habits, and 30% improvement in quality of life scores. When compared to placebo values, satisfaction with bowel habits significantly improved after eight weeks, and intestinal comfort improved after 10 weeks of probiotic intake. Therefore, HMF probiotic strains can be used to promote intestinal comfort and bowel habit satisfaction.
HMF™ Forte also contains the prebiotic fiber fructooligosaccharides (FOS). Prebiotics are non-digestible food ingredients that stimulate the growth and/or metabolic activity of beneficial bacteria in the intestines. They are not broken down or absorbed in the upper part of the gastrointestinal tract, but are fermented in the colon, where they promote a healthy gut flora. Preclinical research suggests that prebiotics such as FOS preferentially target Bifidobacteria and support their growth. Fermentation of prebiotics leads to the production of short chain fatty acids (SCFA), an important energy source for colon cells. In addition, SCFA maintain an acidic intestinal pH, further contributing to a healthy microflora composition. Furthermore, prebiotic fermentation may mediate the intestinal uptake of ions, including iron, calcium and magnesium, promoting their absorption. Preclinical research suggests that prebiotics may also have a role in supporting healthy lipid metabolism.
