Douglas Laboratories Melatonin
Melatonin 3 mg capsules contain 3 mg of high purity melatonin produced under strict Good Manufacturing Practices (GMP) standards.
Each serving contains:
Melatonin - 3 mg
Other ingredients: Microcrystalline cellulose, hydroxpropyl methylcellulose (capsule).
As a dietary supplement, take 1 capsule 1/2 to 1 hour before bedtime or as directed by your healthcare professional.
Melatonin is a natural hormone nutrient that is synthesized from the amino acid tryptophan by the pineal gland in the back of the brain. Melatonin also occurs in small amounts in a variety of foods. In the body, melatonin appears to regulate sleep/wake cycles, support normal immune function, and protect cells from free radical damage. Most of the research on melatonin has focused on its role in maintaining normal sleep/wake rhythms. The perception of daylight in the eyes is a signal for the pineal gland to inhibit melatonin synthesis and release. At night or in the dark, the body’s melatonin production naturally rises to bring on sleep. Nocturnal melatonin production is highest in children and begins to decline from adolescence on.
Melatonin supports the bodies innate immune function by regulating gene expression in macrophages, dendric cells, neutrophils, mast cells and natural killer cells.†It has also been found to support oxidative stress levels, immune defenses and lipid metabolism in acute stress-induced sports performance. Preliminary data from human trials indicate that melatonin has protective effects by balancing cytokine levels. Melatonin is considered an antioxidant that enters all body cells to help prevent free radical damage. In the brain, melatonin is an important physiological antioxidant due to its lipid and water-soluble properties ability to freely cross the blood-brain barrier. In vitro studies show that melatonin is more effective than glutathione in scavenging toxic hydroxyl radicals, and also more efficient than vitamin E in neutralizing peroxyl radicals which can induce DNA damage. Furthermore, melatonin stimulates the main antioxidant enzyme of the brain, glutathione peroxidase.