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With NIAGEN® Nicotinamide Riboside; Decreases the Effects of Cellular Aging
NR Longevity™ targets biological processes that decline with age. Nicotinamide riboside (NR), resveratrol, and sulforaphane promote healthy aging by replenishing NAD+, enhancing mitochondrial function, and providing antioxidant support.
| Serving Size: 2 Vegetarian Capsules | Amount/Serving |
| Nicotinamide riboside chloride (NR) | 300 mg |
| Broccoli (Brassica oleracea italica) sprout concentrate (whole plant) (standardized to contain 800 mcg sulforaphane) |
200 mg |
| Trans-resveratrol | 150 mg |
Other Ingredients: Vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), organic rice extract blend (organic rice bran extract, organic rice hulls, organic gum arabic, and organic sunflower oil).
Does Not Contain: Wheat, soy, dairy, eggs, artificial colors, artificial sweeteners, coatings, shellacs, GMOs, tree nuts, peanuts, sesame, unnecessary binders, fillers, preservatives, magnesium stearate, gluten, trans fat, and hydrogenated oils.
Gluten Free, Non-GMO, Vegan
As a dietary supplement, take 2 capsules, 1-2 times daily, with or between meals.
Warning: If you are pregnant or lactating, have any health condition, or are taking any medication, consult your health professional before use. Keep out of the reach of children.
Storage: Store in a cool, dry place.
What is Nicotinamide riboside (NR)?
Nicotinamide riboside (NR) is a form of vitamin B3 that acts as a precursor of nicotinamide adenine dinucleotide (NAD+), which plays a critical role in cellular energy production.
Supplementing with NR enhances NAD+ levels, supporting the function of NAD+-dependent enzymes that maintain cellular energy production and repair. NR has been clinically shown to increase NAD+ levels in as little as 2 weeks.
Why is NAD+ important for cellular health?
NAD+ activates enzymes in the sirtuin family, the master switches of metabolism and regulators of aging. Notably, NAD+ activates SIRT1, an epigenetic switch that regulates metabolism and supports mitochondrial biogenesis, cellular energy production, and cellular longevity. Higher NAD+ levels are associated with healthy mitochondrial function. Conversely, cellular NAD+ levels decline with age, and can decrease by up to 50% over the adult lifespan.
Aging is associated with a decline in mitochondrial function and increased oxidative stress. NR Longevity™ targets both of these cellular hallmarks by supporting mitochondrial biogenesis and antioxidant gene expression.
Mitochondria are essential to energy production in cells, and their quantity decreases with aging. AMP kinase (AMPK), an enzyme activated by healthy lifestyle habits such as exercise and caloric restriction, increases levels of NAD+, which decline with age.
Nicotinamide riboside (NR) supplementation also increases NAD+ levels. NAD+ enables sirtuin 1 (SIRT1) to activate PGC1alpha, the master inducer of mitochondrial biogenesis (formation of new mitochondria).
Sulforaphane activates Nrf2, a transcription factor that promotes the genetic expression of a wide range of antioxidant proteins, such as superoxide dismutase (SOD) and glutathione biosynthetic enzymes, which help to protect cells from oxidative stress.
