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Ortho Molecular
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Gastrointestinal Health
Ortho Spore Complete is a spore-based, broad-spectrum probiotic formula designed to maintain diversity and balance in the gut microbiota and support gastrointestinal health after SIBO.
A healthy GI tract is a finely balanced environment where countless microbes compete for space and nutrients. Under conditions of health, the ecosystem is balanced (eubiosis), and few GI and extra-intestinal symptoms exist. However, dysbiosis can occur when an overabundance of potentially harmful organisms prevails. Therefore, the health of the GI tract relies on balanced microbiota. A natural balance can be upset by numerous lifestyle factors, such as medications, excessive alcohol consumption, low stomach acid, or poor diet. Probiotics contribute to microbiota balance by positively influencing the intestinal environment via pH balance, microorganism diversity, and immune signaling.
Ortho Spore Complete is specifically formulated with several spore-based probiotic strains to promote diversity and balance within the host gut microbiota. Each capsule provides key Bacillus strains that remain in a dormant, protective state in the harsh GI environment, then become active on target to transiently re-establish and recondition the gut to help prevent small intestinal bacterial overgrowth (SIBO) relapse.
Key Benefits and Features:
| Serving Size: 2 Capsules | Amount/Serving |
| Bacillus coagulans (MTCC5856) (LactoSpore) | 5.9 mg (1 Billion CFU++) |
| Bacillus coagulans (BCP92) | 4.5 mg (1 Billion CFU++) |
| Bacillus clausii (CSI08) | 2.7 mg (1 Billion CFU++) |
| Bacillus subtilis (DE111) | 2.7 mg (1 Billion CFU++) |
| Bacillus subtilis (HU58) | 1.9 mg (1 Billion CFU++) |
Other Ingredients: Maltodextrin (Rice and Sweet Potato), Delayed Release Capsules (Hypromellose, Pectin, and Purified Water), and Medium Chain Triglycerides.
Does Not Contain: Gluten, artificial colors, or flavors.
++Colony Forming Units
Take 2 capsules per day or as recommended by your health care professional.
Warning: If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
Bacillus coagulans (Strains MTCC5856 [LactoSpore®] and BCP92)
Bacillus coagulans supports a balanced microbiota by having antagonistic effects against unwanted organisms and supporting healthy commensal microbes. In an in vitro mechanism study, B. coagulans demonstrated antagonistic action against a variety of undesirable organisms. B. coagulans supplementation at a dose of 1 billion CFU/day for 28 days in adults over age 65 increased fecal concentrations of the commensal F. prausnitzii from baseline compared to placebo; fecal Bacillus spp. also increased in this population.
B. coagulans supports GI health and reduces symptoms related to occasional diarrhea in adults with GI disturbance after 90 days of supplementation. Symptoms of occasional GI discomfort significantly improved in a group of 60 adults supplemented with a blend of 2 billion CFU/day Bacillus probiotic strains for 30 days.
Bacillus clausii CSI08
Bacillus clausii supports GI health, a balanced intestinal microbiota, and immune health. B. clausii has demonstrated significant effectiveness in adults with occasional diarrhea. B. clausii has significantly reduced the duration of occasional diarrhea and decreased stool frequency in a meta-analysis of 1,298 children, with dosages ranging from 2 to 4 billion CFU/day. B. clausii has also shown benefit as a probiotic in subjects with SIBO via normalization of the hydrogen breath test. When given at a dose of 6 billion CFU/day8 B. clausii at an oral dose of 4 billion CFU/day was shown to maintain healthy respiratory function after 90 days in a study of 80 participants.
A recent probiotic attribute analysis study elucidated the survivability and potential health-promoting characteristics of B. clausii CSI08. During in vitro digestive simulation, B. clausii CSI08 demonstrated survivability from the harsh conditions of the upper GI tract, like acidity, pancreatic enzymes, and bile salts. Potential health-promoting attributes of B. clausii CSI08 included adherence to intestinal epithelial cells, synthesis of amino acids and vitamins, down-regulation of inflammatory mediators, and growth inhibition of E. coli, P. aeruginosa, and S. aureus.
Bacillus subtilis (Strains HU58 and DE111®)
Bacillus subtilis has been shown to relieve GI distress in patients. B. subtilis supplementation of 1-3 billion CFU alongside motility-stimulating agents was effective for GI symptom relief at four weeks. Supplementation of B. subtilis with B. coagulans significantly improved stool consistency and symptoms of occasional digestive discomfort (i.e., diarrhea, pain, bloating, excessive flatulence) compared to the placebo group.
