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Pure Encapsulations
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Specialized Pro-Resolving Mediators (SPMs) to Enhance and Sustain Immune Resolution and Restoration of Homeostasis
Pro-Resolve Omega offers a unique blend of marine oils concentrated in Specialized Pro-Resolving Mediators (SPMs). SPMs are a group of compounds derived from marine oils and play a critical role in the resolution of the inflammatory process, including cytokine production and immune cell recruitment and function. Not all inflammation is associated with disease states. The body’s inflammation response to life’s occasional, normal stressors is important for optimal health. The body produces SPMs from fish oil; however, this multi-step process is inefficient and can be compromised.Â
Key Benefits and Features:Â
| Serving Size: 1 Softgel Capsule | Amount/Serving |
| Calories | 10 |
| Total fat | 1 g |
| Cholesterol | 5 mg |
| Marine oil concentrate (from anchovy, sardine, herring, mackerel, and squid) | 1,090 mg |
| providing: | |
| Total omega-3 fatty acids | 560 mg |
| EPA (eicosapentaenoic acid) | 225 mg |
| DHA (docosahexaenoic acid) | 200 mg |
| DPA (docosapentaenoic acid) | 45 mg |
| SPMs | 300 mcg |
|
(including 18-hydroxyeicosapentaenoic acid (18-HEPE), 17-hydroxydocosahexaenoic acid (17-HDHA), and 14-hydroxydocosahexaenoic acid (14-HDHA)) |
 Other Ingredients: Gelatin capsule (gelatin, glycerin, water), natural lemon flavor, and natural mixed tocopherols.
Contains: Fish (anchovy, sardine, herring, mackerel, and squid).
Does Not Contain: Wheat, soy, dairy, eggs, artificial colors, artificial sweeteners, coatings, shellacs, GMOs, tree nuts, peanuts, sesame, unnecessary binders, fillers, preservatives, magnesium stearate, gluten, trans fat, and hydrogenated oils.Â
Gluten Free, Non-GMOÂ
As a dietary supplement, take 1 softgel capsule daily, with a meal.Â
Warning: If you are pregnant or lactating, have any health condition, or are taking any medication, consult your health professional before use.Â
Storage: Store in a cool, dry place.Â
In two studies involving healthy subjects, supplementation with 4-17 grams of fish oil daily did not produce significant increases in SPMs. Different families of resolvins are derived from EPA, DHA, DPA, and AA, and each mediator exerts unique biological actions, such as regulating platelet activation (resolvin E1), regulating immune function (protectins), or promoting tissue health (maresins). Research has focused primarily on the E-series resolvins from 18-HEPE derived from EPA, and the protectins, maresins, and D-series resolvins from 17-HDHA derived from DHA. The omega-3 fatty acid DPA (docosapentaenoic acid) is a precursor for T-series resolvins and has long been associated with vascular health.
In a pool of 19 studies and over 45,000 individuals, DPA was the long-chain essential fatty acid most associated with cardiovascular health. Mechanistic examinations suggest that 15-lipoxygenase (15-LOX), an enzyme that converts DHA and EPA to SPMs, may be critical for SPM production. While levels of EPA and DHA were comparable in immune cells isolated from subjects supplemented with fish oil, cells from obese subjects had compromised levels of 15-LOX and SPM production.
Another study indicated that metabolic factors may influence levels of SPM precursors in response to fish oil supplementation. In healthy volunteers, supplementation with fish oil with SPM increased immune cell efficacy and decreased expression of adhesion molecules and platelet activation.
