Enter Discount Code 10HEALTHY at checkout for $10 off orders of $100 or more! Brand exclusions apply - Click for details
Healthy Habits Living is an authorized retailer of
Pure Encapsulations
products.
Rapid-Acting Support for Occasional Anxiety (<1 hr)
Rapid Calm combines vitamin B6 with two clinically researched ingredients, Zembrin®, a patented extract of Sceletium tortuosum, and Suntheanine® L-theanine, to help moderate feelings of stress and occasional anxiety. This formula is ideal for as-needed relief from occasional everyday stressors.
Key Benefits and Features:
| Serving Size: 1 Vegetarian Capsule | Amount/serving |
| Vitamin B6 (as pyridoxine HCI) | 10 mg |
| Zembrin® Sceletium tortuosum extract (aerial parts) |
25 mg |
| L-Theanine (Suntheanine®) | 200 mg |
Other Ingredients: Hypoallergenic plant fiber (cellulose), vegetarian capsule (cellulose, water), and ascorbyl palmitate.
Does Not Contain: Wheat, soy, dairy, eggs, artificial colors, artificial sweeteners, coatings, shellacs, GMOs, tree nuts, peanuts, sesame, unnecessary binders, fillers, preservatives, magnesium stearate, gluten, trans fat, and hydrogenated oils.
Non-GMO, Gluten Free, Vegan, Vegetarian
As a dietary supplement, take 1 capsule as needed, with or between meals, or as directed by a health professional.
Warning: Not to be taken by pregnant or lactating women. If you have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach of children.
Storage: Store in a cool, dry place.
WHO IS THIS SUPPLEMENT FOR?
Patients experiencing feelings of occasional stress or anxiety.
RESEARCH HIGHLIGHTS
Zembrin® reduces occasional anxiety. In a randomized, placebo-controlled clinical trial, a single dose of 25 mg Zembrin® 30 minutes before a simulated public speaking task reduced perceived anxiety level and its physical symptoms, such as elevated heart rate, in healthy volunteers.
Zembrin® reduced activity of the amygdala and its associated circuitry within 2 hours of administration.
In a randomized clinical trial, a single 25 mg dose of Zembrin® moderated fear responsivity and activation of the brain's amygdala, assessed using functional Magnetic Resonance Imaging (fMRI) technology. The amygdala is a part of the brain that perceives threats and dictates behavior in stressful situations.
L-theanine (Suntheanine®) reduced stress-related symptoms and supported sleep quality in healthy adults.
In a double-blind crossover trial, 30 healthy adults received L-theanine (200 mg Suntheanine®/day) or placebo for 4 weeks. L-theanine significantly improved stress-related symptoms, including low mood symptoms and occasional anxiety, per validated questionnaires and sleep (Pittsburgh Sleep Quality Index; PSQI) scores compared to placebo.
MECHANISMS OF ACTION
The mechanism of action of Zembrin® remains unclear. In vitro, Zembrin® and its principal alkaloids, mesembrine and mesembrenone, inhibited the serotonin reuptake transporter. This action may prolong the effects of serotonin, a neurotransmitter with mood-elevating effects.
Vitamin B6 is a cofactor for aromatic amino acid decarboxylase (AADC), a key enzyme in serotonin production. This enzyme uses pyridoxal 5'-phosphate (activated vitamin B6) to convert 5-HTP to serotonin.
L-theanine increases alpha wave activity in human electroencephalograms (EEG), which indicates a relaxed mental state without sedation or drowsiness. L-theanine supports inhibitory neurotransmission by enhancing GABA signaling while inhibiting excitatory neurotransmission. L-theanine is an analog of glutamate, the major excitatory neurotransmitter in the brain.
By virtue of its structural similarity, L-theanine competes with glutamine for uptake into presynaptic terminals. This limits the synthesis and abundance of glutamate available for release into the synapse and subsequent activation of glutamate receptors.
