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Cardiovascular Health
RegeneVasc is formulated to strengthen the endothelial glycocalyx by providing the foundational building blocks that make up this delicate defensive barrier.
The endothelial glycocalyx (eGCX) is a dense, gel-like meshwork that covers the endothelial cell layer. It makes up an important physical barrier in the vasculature that prevents lipids and other particles from adhering to and entering the endothelium. This special network of membrane-bound proteoglycans and glycoproteins has a profound influence at the vascular wall on the transmission of shear stress and pressure, the maintenance of selective permeability, and the control of, adhesion of blood leukocytes and platelets.
RegeneVasc provides a blend of the major constituents of the eGCX, including glycosaminoglycans, hyaluronan, fucoidan and marine polyphenols, which are designed to protect and regenerate the eGCX.
Key Benefits and Features:
| Serving Size: 2 Capsules | Amount/Serving |
| Calories | 5 |
| Total Carbohydrate | 1 g |
| Sodium |
60 mg |
| Proprietary Blend | 1.38 g |
| Fucus vesiculosus Seaweed Extract (Whole Plant) (Maritech® Synergy) (Contains Fucoidan and Polyphenols) | |
| Chondroitin Sulfate Sodium | |
| Chicken Comb Extract (MOBILEE®)(Standardized to contain 40 mg Hyaluronic Acid) |
Other Ingredients: Hypromellose (Natural Vegetable Capsules), Microcrystalline Cellulose, Magnesium Stearate, and Silicon Dioxide.
Contains: Crustacean Shellfish (Shrimp) and Fish (Cod).
Does Not Contain: Gluten, corn, yeast, artificial colors, or flavors.
Take 2 capsules per day or as recommended by your health care professional.
Warning: Do not consume this product if you are pregnant or nursing. Consult your physician for further information. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
Mobilee® Hyaluronic Acid Matrix
Mobilee® is a hyaluronic acid matrix ingredient extracted from rooster comb that contains a high concentration of hyaluronic acid (60-75%) and other components, including polysaccharides (>10%) and collagen (>5%). Hyaluronic acid is a substance naturally produced by the body and present in our joints, skin, and other organs. It is present in the endothelial glycocalyx and plays a central role in numerous functions of the endothelial surface layer, such as protecting the endothelial cells, regulating barrier permeability, and ensuring mechanosensing, which is essential to nitric oxide production and flow-induced vasodilation. According to research, the shedding of syndecan-1, heparan sulfate, and hyaluronic acid has been claimed to represent the endothelial glycocalyx state of health. The quality and quantity of hyaluronic acid the body produces decrease with age. Tested in 11 clinical and pre-clinical studies, Mobilee® has been shown to provide a tenfold increase in the endogenous synthesis of hyaluronic acid by synoviocytes.
Chondroitin Sulfate
Chondroitin sulfate is the second most abundant component of the eGCX.9 In addition to functioning as a vital component of the eGCX, chondroitin sulfate stimulates the synthesis of other glycosaminoglycans (GAGs) of the eGCX, like heparan sulfate and hyaluronan.
Compared to glucosamine sulfate, chondroitin sulfate provides superior eGCX support due to its role as a precursor and source component of the eGCX, which is one of several mechanisms of action hypothesized for chondroitin sulfate’s cardioprotective benefits. The conversion of glucosamine sulfate to other GAGs can also be inhibited by non-steroidal anti-inflammatory drugs.
Chondroitin sulfate has inhibitory effects on catabolic enzymes like elastase, collagenase, and proteoglycanase, structures that are rich in all layers of blood vessels. Another proposed cardioprotective mechanism is the ability of chondroitin sulfate to maintain normal inflammatory balance because it decreases the expression of TNF-α, IL-1β, IL-6, and COX-2.
In an NHANES study sample, 658 participants had been taking glucosamine and chondroitin for one year or longer. Respondents taking glucosamine and chondroitin had better cardiovascular health and wellness than controls. After controlling for age, this combination was associated with a 65% reduction in cardiovascular challenges. Finally, a case-control study that investigated the cardiovascular health and wellness of 140,990 adults from 2002-2015 found that those who supplemented with chondroitin sulfate had a lower likelihood of cardiovascular challenges.
Maritech® Synergy
RegeneVasc contains Maritech® Synergy, a proprietary, multifunctional, certified organic complex that combines the synergistic effects of specialized polyphenols and fucoidan sourced from the wild brown seaweed known as Fucus vesiculosus. In fact, of the three groups of seaweed, brown seaweed is known to contain more bioactive components than either red or green seaweed. Among the different brown seaweed species, Ascophyllum nodosum and Fucus vesiculosus have the highest antioxidant values and the highest total phenolic content. Therefore, fucoidan from brown seaweed is a powerful glycocalyx regenerating compound and has been reported to possess many cardiovascular health benefits. For example, fucoidan potently inhibits selectin-mediated adhesion of leukocytes to vascular endothelium.
In addition to fucoidan, phlorotannins are a heterogeneous group of unique polyphenolic compounds differing in structure and degree of polymerization and are found only in brown seaweed, with the largest amount accumulating in Fucus brown seaweed. Phlorotannins have very strong antioxidant properties since phenolic rings act as electron traps for free radicals. These bioactive compounds have been shown to help maintain normal inflammatory balance, modulate immune cell signaling, and even maintain blood sugar levels already within the normal range.
One study showed that the administration of Fucus vesiculosus is effective in reducing microvascular fat retention and improving glycemic control, thereby lowering the risk of health challenges related to the consumption of fat and sugar-enriched diets. The fucoidan sulfate in RegeneVasc has an analogous chemical structure to heparan sulfate, which is found amply in the endothelial glycocalyx. In vitro studies by Marinval, et al. demonstrated that fucoidan can directly connect with the glycocalyx, prevent its degradation, and help to restore its structure and function. Glycocalyx restoration and other beneficial mechanisms of action support the therapeutic use of fucoidan and phlorotannins from Fucus vesiculosus for cardiovascular wellness.
