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Healthy Habits Living is an authorized retailer of
Ortho Molecular
products.
Specialty Applications
As a donator of methyl groups, SAMe supports glutathione production, liver health, musculoskeletal and joint comfort, and a positive mood.
S-Adenosylmethionine (SAMe) is the active methyl form of the amino acid methionine. SAMe is necessary for an array of biochemical pathways, including neurotransmitter synthesis, metabolism of homocysteine, and detoxification. As a donator of methyl groups, SAMe supports glutathione production, liver health, musculoskeletal and joint comfort, and a positive mood.
SAMe is a principal methyl donor for biochemical reactions throughout the body. This methyl transfer is critical to reactions involving proteins, phospholipids, DNA, RNA, creatine, hormones, the development of cell membranes, the degradation of histamine, and the formation of norepinephrine and dopamine.
Key Benefits and Features:
| Serving Size: 2 Capsules | Amount/Serving |
| Folate (from 400 mcg as Quatrefolic (6S)-5-Methyltetrahydrofolic acid glucosamine salt) | 680 mcg DFE |
| SAMe (as S-Adenosyl-L-methionine disulfate p-toluensulfonate) | 400 mg |
Other Ingredients: None.
Does Not Contain: Gluten, corn, yeast, artificial colors, or flavors.
Take 1-2 capsules two times per day or as recommended by your health care professional.
Warning: This product should not be taken with any anti-depressant drugs (MAO Inhibitors, bicyclic, tricyclic, Fluoxetine, etc.) unless under the close supervision of your health care professional. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
Deficiency
SAMe levels tend to decline as people age. In addition, SAMe is used in the production of the mood-elevating neurotransmitter serotonin as a methyl donor. Low levels of SAMe have been associated with certain mood challenges.
Detox Support and Antioxidant Protection
SAMe is an essential molecule in the synthesis of glutathione, a key component of antioxidant and detoxification.5 After donating a methyl group, SAMe is converted to S-adenosylhomocysteine (SAH), a reaction that promotes the trans-sulfuration pathway in the liver that produces glutathione. SAH is then broken down to trimethylglycine (TMG), or betaine anhydrous, which plays an important role in maintaining a healthy SAMe: SAH ratio in the liver. Studies show SAMe supports liver health and positively affects the cell-life regulation of hepatocytes.
Mood Health
SAMe appears to support mood health, possibly due to its active role in methylation and involvement in the formation of monoamine neurotransmitters. A meta-analysis showed SAMe supported a healthy mood compared to a placebo, with an effect comparable to that of other treatments. A 30-day, double-blind, placebo-controlled, randomized study of 80 women suggested that there was a significant improvement in mood after the women received an oral dose of 1,600 mg/day of SAMe compared to placebo. Another study of 143 subjects who received an oral dose of 1,600 mg/day of SAMe suggested that SAMe yielded positive results that were comparable to other treatments for supporting a healthy mood, but SAMe was better tolerated. In a small, four-week, double-blind, randomized trial comparing oral SAMe with other treatments, 62% of the SAMe group showed significant improvement in mood, and the study revealed a significant correlation between plasma SAMe levels and the degree of healthy mood support, regardless of treatment type.
Folate
Folate is a water-soluble member of the B-complex vitamins that is critical for maintaining optimal methylation pathways. Malabsorption and genetic defects in the enzyme 5-methyltetrahydrofolate reductase (5-MTHFR) can result in an impaired ability to activate folic acid. Folic acid supports the trans-methylation pathway, which metabolizes homocysteine into cysteine. Increases in oxidative stress may shift homocysteine metabolism towards trans-sulfuration to increase hepatic production of reduced glutathione.
