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Enhanced-Stability SAMe to Support Methylation, Positive Mood, Glutathione Production, and Joint Comfort
SAMe (S-adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation, and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. Healthy methylation is vital for cellular health, hormone and neurotransmitter production, and energy metabolism.
SAMe also functions as a precursor molecule for glutathione and promotes polyamine synthesis to promote healthy cellular function. The polyamines spermidine and spermine maintain healthy cell growth and cytokine balance.
Key Benefits and Features:
| Serving Size: 1 Vegetarian Capsule | Amount/Serving |
| SAMe (S-adenosylmethionine) (from S-adenosyl-L-methionine disulfate tosylate) | 200 mg |
Other Ingredients: Vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), calcium oxide, ascorbyl palmitate, and calcium chloride.
Does Not Contain: Wheat, soy, dairy, eggs, artificial colors, artificial sweeteners, coatings, shellacs, GMOs, tree nuts, peanuts, sesame, unnecessary binders, fillers, preservatives, magnesium stearate, gluten, trans fat, and hydrogenated oils.
Gluten Free, Non-GMO, Vegan, Vegetarian
As a dietary supplement, take 1 capsule, 1-2 times daily, between meals, or as directed by a health professional.
Warning: If you are pregnant or lactating, have any health condition, or are taking any medication, particularly if you have bipolar disorder or are taking antidepressant medication, consult your health professional before use.
Storage: Store in a cool, dry place.
Clinical trials indicate that SAMe administration enhances glutathione production in hepatic tissue and red blood cells. SAMe also supports cognitive function and mood. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood.4 While the exact mechanism for this benefit has not been determined, it is believed that SAMe supports neurotransmitter monoamine synthesis and function, including dopamine and serotonin, through SAMe-dependent methylation reactions.
By supporting methylation, SAMe promotes phosphatidylcholine production and cellular membrane integrity and fluidity.6Multiple clinical trials indicate that SAMe supports joint comfort and flexibility. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. In another 16-week, randomized, double-blind, placebo-controlled trial involving 56 subjects, SAMe offered statistically significant support for joint comfort. It is believed that SAMe enhances joint comfort and function by supporting proteoglycan synthesis and by helping to stabilize and protect the proteoglycans.
