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Ther-Biotic® Saccharomyces boulardii Default Category Klaire Labs 120 Vegetarian Capsules
Ther-Biotic® Saccharomyces boulardii Default Category Klaire Labs
Ther-Biotic® Saccharomyces boulardii Default Category Klaire Labs
Ther-Biotic® Saccharomyces boulardii Default Category Klaire Labs 60 Vegetarian Capsules

    Ther-Biotic® Saccharomyces boulardii



    Klaire Labs Ther-Biotic® Saccharomyces boulardii

    Supports Healthy Intestinal Microflora and GI Function Probiotic Yeats Formula

    Saccharomyces boulardii is a non-pathogenic, transient yeast long used to support normal bowel transit time. It is a hardy, acid-resistant, temperature tolerant microorganism that is not affected by antibacterial agents. S. boulardii is genetically and functionally distinct from brewer’s yeast (S. cerevisiae) and different from pathogenic Candida species.

    S. boulardii increases the activities of intestinal brush border enzymes such as disaccharidases, a-glucosidases, alkaline phosphatases, and aminopeptidases.

    S. boulardii augments the intestinal absorption of D-glucose coupled with sodium that may enhance the uptake of water and electrolytes during occasional diarrhea. It increases stool concentrations of short-chain fatty acids that nourish colon mucosal cells. S. boulardii modulates immunity by boosting intestinal secretion of IgA and increasing crypt cell immunoglobulin receptors. It supports a healthy inflammatory response, where inflammation is associated with occasional digestive discomfort. Research has found that S. boulardii supports healthy intestinal function in an array of clinical settings, supporting healthy bowel transit time.

    S. boulardii is also an important ingredient in ABx Support™, supplying 5 billion CFUs.

    Note: Saccharomyces boulardii probiotic is a natural ingredient and variations in color are due to naturally occurring differences in ingredients.

    Benefits and Features:

    • A powerful, unique, non-pathogenic yeast probiotic
    • Assists individuals with occasional diarrhea
    • Supports healthy inflammatory response, where inflammation is associated with occasional digestive discomfort
    • A beneficial yeast that stimulates the immune system and promotes digestive health
    • Clean, hypoallergenic formulations
    • 3 billion CFU in a cellulose base. Capsules suitable for FODMAP and vegetarian/vegan diets
    • Pure S. boulardii powder with multi-dose (9-45 billion CFU) measuring scoop for titration protocol accuracy
    • Heat-stable formula maintains potency when refrigeration is not possible

    Clinical studies show that S. boulardii supports healthy intestinal function, promoting healthy bowel transit time.

    Ther-Biotic® Saccharomyces boulardii is also available in a powder


    Serving Size: 1 Vegetarian Capsule
    Probiotic Blend in a base of cellulose 273 mg
    Saccharomyces boulardii 3 Billion CFU

    Other Ingredients: Vegetarian capsule (hydroxypropyl methylcellulose, water) and L-leucine.

    Made without common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/gluten, soybeans and sesame. No synthetic colors, flavors, or preservatives. Non-GMO, Vegetarian.

    Suggested Use

    Adults: 1 capsule twice daily or as directed by a healthcare professional.

    S. boulardii is generally used for short-term gastrointestinal support. Often the S. boulardii has been used for up to 2 weeks after a bout of occasional diarrhea has resolved. A common supplement regimen lasts 3 to 4 weeks.

    Children: As directed by a healthcare professional.

    Caution: Not recommended for severely immunocompromised individuals or those with central venous catheters. Consult with your physician if you are pregnant or lactating, or have any medical condition, or taking prescription drugs, or under the age of 12. consult your healthcare professional before using this product. Keep out of reach of children. KEEP OUT OF REACH OF CHILDREN.

    Storage: Store in a cool, dry place (59ºF to 85ºF) away from direct light. Keep out of reach of children.

    More Info.

    Saccharomyces boulardii is a nonpathogenic, transient yeast. Since its discovery in 1920, clinicians worldwide have used S. boulardii to support normal bowel transit time, promote healthy immune and inflammatory processes in the digestive tract, and bolster gastrointestinal microbiota diversity, particularly in conjunction with antibiotic therapy. S. boulardii is also commonly used to safely and effectively displace undesirable yeast species.

    Mechanisms of Action:

    • Promotes intestinal brush border membrane enzyme activity
    • Augments intestinal D-glucose and sodium absorption for improved hydration during occasional diarrhea
    • Interferes with cellular signaling pathways via toxin inhibition/cleavage and stimulates endogenous IgA to promote a healthy inflammatory response
    • Inhibits non-beneficial bacteria from binding to the digestive tract
    • Decreases pseudohyphae to diminish undesirable yeast adhesion and biofilm formation

    S. boulardii has a long track record of demonstrated efficacy in both animal experiments and human clinical trials to support gastrointestinal health. As recently as 2016, the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition based their recommendation for use of S. boulardii on its quality of evidence.

    In 2014, a pooled data review of 22 qualifying studies concluded that S. boulardii is a safe and effective approach to reducing the frequency and duration of occasional diarrhea. A more recent 2016 review suggests S. boulardii may promote these positive outcomes by acting directly on non-beneficial species or their toxins and by supporting host immune signaling cascades and innate and adaptive immune system responses.

    In an additional 2015 meta-analysis of 11 randomized, controlled trials involving 2,200 subjects (including 330 children), administration of S. boulardii during triple therapy for a non-beneficial bacterium resulted in significantly improved outcomes and decreased adverse effects compared to controls.

    Use of S. boulardii to effectively compete with undesirable yeast species is also a common practice, based on its ability to inhibit adhesion and influence inflammatory response as demonstrated in in vitro studies by Murzyn and colleagues.

    In addition to promoting beneficial bacteria and yeast in the digestive tract, S. boulardii supplementation also has pronounced effects on digestive enzymes of the brush border membrane and has been demonstrated to enhance nutrient acquisition for the host.

    Does Saccharomyces boulardii colonize the intestinal tract?

    S. boulardii does not colonize the human intestinal tract and is not one of the microorganisms that normally inhabit the intestines. It is a transient yeast that passes through the intestines after ingestion. S. boulardii does not attach to the mucosal cells lining the intestines, but exerts its beneficial effects on the host as it moves through the gastrointestinal tract.

    Is Saccharomyces boulardii the same as Saccharomyces cerevisiae?

    No, S. boulardii is not S. cerevisiae. S. boulardii is a wild, tropical yeast while S. cerevisiae is commonly known as brewer’s or baker’s yeast. Closely related to S. cerevisiae, S. boulardii is officially classified as Saccharomyces cerevisiae var boulardii Hansen CBS 5926. The 2 species have different genetic makeup and enzyme profiles. Unlike S. cerevisiae, S. boulardii does not make a certain type of reproductive spore called an ascospore and does not use the sugar galactose. It is very resistant to heat and acid and secretes a number of unique physiologically active factors. Only S. boulardii has proven gastrointestinal supportive effects.

    What are the primary uses for Saccharomyces boulardii?

    S. boulardii has been used to positively affect gastrointestinal function in the following situations:

    • support the normal gastrointestinal microbiota during antibiotic use
    • assist individuals with occasional diarrhea
    • favorably modulate the normal gastrointestinal microbiota
    • assist the body’s natural gastrointestinal detoxification process
    • support host immune defenses and gut barrier function