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Healthy Peripheral Circulation, Glucose Metabolism, and AGE Activity
Ultra Benfotiamine contains the fat-soluble thiamine vitamin called benfotiamine, plus activated vitamin B6, alpha lipoic acid, grape seed extract, and pine bark extract to support healthy peripheral neuronal function, circulation, and kidney function. Research suggests that benfotiamine helps to moderate AGE (advanced glycation end product) formation, a process related to glucose metabolism.
| Serving Size: 1 Vegetarian Capsule | Amount/Serving |
| Pyridoxal-5-Phosphate (activated B6)Â | 25 mg |
| Benfotiamine (as BenfoPure) | 150 mg |
| Alpha Lipoic Acid (MegaNatural-BP) | 100 mg |
| Grape Seed Extract (Vitis vinifera) (standardized to 90% polyphenols)Â | 25 mg |
| Enzogenol Pine Bark Extract | 10 mg |
Other Ingredients: Hydroxypropyl methylcellulose (capsule), cellulose, dicalcium phosphate, vegetable stearate, and silica.
Does Not Contain: Yeast, wheat, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives, or flavoring.
Adults take 1 capsule twice daily or as directed by your healthcare professional.
Warning: No adverse effects have been reported. Keep out of reach of children.
Storage: Store in a cool, dry place, away from direct light.Â
BenfoPure® is a unique proprietary form of Benfotiamine, a fat-soluble form of Vitamin B-1 Thiamine.  Studies show that BenfoPure® Benfotiamine is significantly more bioavailable than traditional forms of Vitamin B-1 or thiamine.  Its mechanism of action is through blocking biochemical pathways by which high blood sugar damages cells. Â
Advanced glycation end products (AGEs) are proteins or lipids that become glycated after exposure to sugars. The presence and accumulation of AGEs in many different cell types affect extracellular and intracellular structure and function. In high blood sugar environments and in natural aging, AGEs alter cell structure and normal vascular function. Benfotiamine supports normal endothelial function by reducing the risk of AGEs, which is associated with optimal cardiovascular health.
Vitamin B6 has been shown to help provide comfort for peripheral nerves, especially in those individuals with pyridoxine deficiency. Â Pyridoxal-5-Phosphate (P5P) is the active form of pyridoxine that the body utilizes directly without need for conversion from pyridoxine. Â Alpha lipoic acid (ALA) is among the well-researched nutrients for support of peripheral nerve function. Â ALA may normalize nitric oxide levels to support increased circulation to the neurons. Â In animal research, ALA supplementation resulted in increased blood flow and nerve conduction.Â
Proanthocyanidins are a class of potent antioxidants found in pine bark extract, grape seed extract, and many other plants. OPC (oligomeric proanthocyanidins) neutralize free radicals, support the strength and structure of blood vessels.  MegaNatural® BP Grape seed extract is different from other grape seed extracts and made by a patented water extraction process that yields a pure extract with a low molecular weight.  Mega Natural BP extract contains over 90% proanthocyanidins. Studies in humans have shown it supports healthy arterial and endothelium cell function.Â
