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Cardiovascular, Immune & Musculoskeletal Health
A comprehensive multi-enzyme formula, Vascuzyme helps support normal blood circulation and vessel function, and maintains normal inflammatory balance.
Vascuzyme, a comprehensive multi-enzyme formula, helps support normal blood circulation and vessel function, and maintains normal inflammatory balance. It also promotes recovery from exercise and physical stress by supporting the breakdown of unwanted proteins, aiding the body’s natural repair processes. For a normal recovery process, Vascuzyme has applications for a broad range of health needs. Vascuzyme’s enzyme blend includes protease, amylase, papain, trypsin, lipase, chymotrypsin, bromelain, and peptidase enzymes, along with quercetin and rutin, two well-known flavonoids.
Enzymes are complex proteins that catalyze metabolic reactions throughout the body, and sufficient levels are required for optimizing many of the body’s functions. Although the body produces its own supply of enzymes, the amount produced can vary from person to person and is affected by age, diet, biochemistry, and stress. Enzymes fall into three broad categories: metabolic enzymes, manufactured by cells to carry out various functions; digestive enzymes, primarily manufactured by the pancreas to digest foods and absorb nutrients and food enzymes; and exogenous (from outside the body) enzymes from plants and animals, also necessary for aiding and accelerating digestion. Systemic enzymes support the breakdown of unneeded proteins, which research has shown to be an important component of cardiovascular health and supporting optimal blood vessel function. In cases of soft tissue discomfort from post-exercise pain, systemic enzymes help break down fibrin to support areas of inflammation and reduce recovery times. Research has shown that proteolytic enzymes are well-absorbed from the gastrointestinal tract into the systemic circulation.
Key Benefits and Features:
| Serving Size: 2 Capsules | Amount/Serving |
| Pancreatin | 450 mg |
| Protease (from Pancreatin) (90,000 USP Units) | |
| Amylase (from Pancreatin) (90,000 USP Units) | |
| Lipase (from Pancreatin) (7,200 USP Units) | |
| Papain (1,080,000 USP Units) | 180 mg |
| Trypsin (18,000 USP Units) | 72 mg |
| Chymotrypsin (2,025 USP Units) | 27 mg |
| Bromelain (from Pineapple) (324 GDU) | 135 mg |
| Peptidase (24,000 Serratiopeptidase Units [SPU]) | 40 mg |
| Quercetin Dihydrate | 75 mg |
| Rutin | 75 mg |
Other Ingredients: Hypromellose (Natural Vegetable Capsules), Microcrystalline Cellulose, Silicon Dioxide, and Magnesium Stearate.
Does Not Contain: Gluten, yeast, artificial colors, or flavors.
Take 2 capsules per day on an empty stomach, or as recommended by your health care professional.
Warning: If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
Research
Studies have highlighted the efficacy of systemic enzyme therapy for a variety of uses, including maintaining normal inflammatory balance, nasal passage health, bronchial health, musculoskeletal health, and exercise-related recovery. In vitro, animal and human data show that enzyme therapies are capable of cleaving immune complexes, which are known inflammatory mediators. In one study, among four different types of immune complexes prepared in vitro and incubated with different concentrations of an enzyme mixture (papain or pancreatin), approximately 90% of the antigen complexes were cleaved by low doses of enzymes. In addition, antibody complexes were gradually cleaved by concentrations from 5-80 mg.
Proteolytic enzymes have also been shown to reduce levels of the immune marker, TGF-β (Transforming Growth Factor beta), by converting the protease inhibitor alpha2M from the slow form into the fast form, which binds and inactivates TGF-β. In one study, oral proteolytic enzyme therapy reduced TGF-β levels, maintaining normal inflammatory balance. A study done in children who were given either a polyenzyme mixture or a monoenzyme agent found that those receiving the polyenzyme mix maintained an optimal balance of proinflammatory cytokines (IL-2, IL-6, and TNF-α). Additionally, the beneficial cytokine IL-4 demonstrated the potency of polyenzyme therapy to maintain normal inflammatory balance and promote tissue recovery.
In addition, enzyme therapy supports improvements in discomfort, stiffness, and mobility among those with musculoskeletal challenges. Researchers also found significant improvements among 103 patients with minor knee complaints given enzyme therapy.
Strong peptidase enzymes have been used in both Japan and Europe for maintaining normal inflammatory balance since the early 1980s, with systematic reviews supporting their beneficial role in lowering the release of harmful amines in various tissues, balancing the body's systemic inflammatory burden, as well as supporting the breakdown of unwanted proteins without affecting healthy tissues. Additionally, in an animal study, similar enzymes were found to be effective as more traditional options for maintaining normal inflammatory balance.
Research has also shown that flavonoids, such as rutin and quercetin, maintain normal inflammatory balance. Specifically, they have been shown to reduce the production of TNF-α by macrophages, microglial cells, and mast cells, helping to maintain normal inflammatory balance. In a randomized, single-blind study on the antioxidant effect of rutin, after six weeks, those receiving rutin had significantly elevated plasma flavonoids (quercetin, kaempferol, and isorhamnetin), displaying the powerful antioxidant effect of rutin. Quercetin was also found to decrease the expression and production of TNF-α, IL-1β, IL-6, and Il-8. Finally, systemic enzyme therapy has been shown to stimulate internal defenses to support a normal musculoskeletal inflammatory response. Systemic enzyme therapy has been shown to modulate cytokine levels and shift “immune balance” toward a calm, efficient immune state.
