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Cardiovascular & Musculoskeletal Health
Supplementing vitamin D3 and K2 can help promote bone health and maintain health cardiometabolic function. Ortho Molecular Products is the exclusive provider of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7.
New research is focusing on the synergistic relationship between vitamin K2 and vitamin D3 for bone and cardiovascular health. A group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is essential for the proper utilization of calcium. Through its activation of the protein osteocalcin, vitamin K helps to bind newly absorbed calcium to the mineral matrix in bone. In addition, vitamin K has been found to help maintain bone mineral density by decreasing the activity of osteoclasts, a cell that breaks down the bone matrix. Vitamin K also provides critical cardiovascular protection by helping to activate matrix Gla protein (MGP), an inhibitor of circulatory calcification. Thus, vitamin K and vitamin D not only share similar qualities, but they also act synergistically within the body.
The addition of MenaQ7® PRO to this formula is backed by extensive research. Dr. Leon Schurgers, world-renowned expert in vitamin K2 as MK-7 research for cardiovascular and bone health, and his team of research scientists have conducted over 15 clinical trials on MenaQ7® PRO through the University of Maastricht.
Vitamin K2 with D3 includes 45 mcg of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7, and 5,000 IU of vitamin D3 per capsule for optimal absorption and use by the body.
Key Benefits and Features:
| Serving Size: 1 Capsule | Amount/Serving |
| Vitamin D (D3 as Cholecalciferol) | 125 mcg (5,000 IU) |
| Vitamin K2 (as Menaquinone-7 (MK-7)) (MenaQ7PRO) | 45 mcg |
Does Not Contain: Microcrystalline Cellulose, Hypromellose (Natural Vegetable Capsule), Magnesium Stearate, Silicon Dioxide, and Stearic Acid.
Does Not Contain: Gluten, yeast, artificial colors, or flavors
Take 1 capsule per day, or as recommended by your health care professional.
Warning: If you are pregnant or nursing, consult your physician before taking this product. All forms of Vitamin K may interact with blood-thinning medications. If you are taking such medicines, please consult with your physician before taking this product. Keep out of the reach of children.
Storage: Keep tightly closed in a cool, dry place.
Vitamin K Depletion
Although most people consume adequate dietary vitamin K to maintain sufficient blood clotting, most do not consume enough to meet cardiovascular and bone health needs. In fact, approximately 70% of the Western population is deficient in vitamin K2. Compromised intestinal absorption can also lead to insufficient K2 levels, leaving calcium available to be exported out of bone and into other tissues. Other medications, such as antibiotics, cholesterol-lowering medications, and laxatives, have also been found to contribute to a deficiency of vitamin K.
Bone Health
Building and maintaining healthy bones requires a number of key nutrients, including vitamin K, for the proper binding of calcium to the bone matrix. A 2005 study from northern Finland found that those with greater levels of vitamin K-carboxylated osteocalcin had stronger bones than those with lower levels of the protein. A Japanese study found superior bone health among women who were frequent MK-7-rich natto eaters than those who were not. Another randomized study, which split 172 women into a vitamin K2 group, a vitamin D3 group, a vitamin K2 and D3 group, and a placebo group for two years, found that the combination of vitamin D3 and K2 had the most benefits for supporting bone health among the groups.
Cardiovascular Health and Blood Sugar Balance
Vitamin K plays a key role in supporting the cardiovascular system as well as blood sugar balance already within normal levels. In a large population study, researchers found that those who consumed high amounts of K2 had significantly better cardiovascular health markers compared to those given vitamin K1. Studies have also shown that Vitamin K supports healthy blood sugar metabolism.
Immune Modulation
New evidence also suggests vitamin K plays a central role in balancing immune health. Recent studies have shown that both vitamins D and K impart immune-modulating effects. In the Framingham Offspring Study, one of the longest-standing studies on generational health, higher serum levels of vitamins D and K were associated with stronger immune function and a balanced inflammatory response. In a 2011 study, vitamin K was also found to suppress various markers of the immune system.
Triage Theory
The Triage Theory states that in the face of nutrient inadequacies, nature ensures the short-term survival of a cell is protected at the expense of long-term consequences.20,21 Vitamin K is an excellent example of this theory. Hypothetically, a short-term deficiency in vitamin K would lead to a reduction in blood clotting. This direct threat to survival does not happen, as the body uses its metabolic reserve of vitamin K to ensure immediate needs are met. If continued, this could begin to impact long-term reserves of vitamin K, reserves which are vital for the maintenance of proper bone strength and arterial elasticity. These issues are related to a loss of vitamin K-dependent proteins not required for short-term survival; nevertheless, presenting long-term health challenges.
