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BioPure’s Formulas From the Bottom Up

by Carly Neubert, BA, NC on April 12, 2023

BioPure has made a name for itself with its natural, effective, and potent products. Not only have they continuously brought relief and wellness benefits to some of our sickest clients, but they are always looking for new ways to improve. Their testing processes are rigorous, as are their ingredient-sourcing procedures. They focus on obtaining ingredients from reputable farmers, both domestic and international. Choosing manufacturing processes that yield the highest ingredient potency allows them to provide high-quality and tested products. 

BioPure’s formulas have always emerged from necessity. Dr. Klinghardt, the founder and formulator for BioPure, treats chronic and complex illnesses such as Lyme disease, mold illness, PANS/PANDA and post-covid illness. These are illnesses that don’t respond to your run-of-the mill protocols and formulas. Many chronic illness patients, including me, are sensitive and reactive to just about everything. So quality and purity in ingredients and manufacturing is a top priority.  

You may be wondering, why use suppositories? The rectal route is much more direct and faster for most nutrients. Many nutrients are hard to absorb, can cause nausea, or are partially lost in the digestive process. That means you have to take higher doses just to get the nutrient into your bloodstream.  However, using a suppository literally bypasses your digestive system, and enters your bloodstream via the vessels in your rectum.  Additionally, most people with chronic health challenges have poor digestion and are already taking dozens of supplements and/or medications per day. 

BioPure suppositories utilize organic cocoa butter, botanicals, and additional synergistic ingredients that provide targeted support. Cocoa butter melts easily in the body and has been used for centuries to soothe the skin. 

Bravo Suppository

The first suppository I will be discussing is the Bravo Suppository. This is a probiotic suppository that provides both probiotics and colostrum. The colostrum is high-quality, organic, and freeze-dried. The probiotic strains in this formula are commonly seen in yogurt and kefir. The probiotic strains in this suppository include: 

  • Lactobacillus acidophilus
  • Lactobacillus salivarius
  • Lactobacillus rhamnosus
  • Lactobacillus paracasei
  • Lactococcus lactis
  • Lactobacillus bulgaricus
  • Streptococcus thermophilus
  • Bifidobacterium infantis
  • Bifidobacterium bifidum
  • Bifidobacterium longum
  • Bifidobacterium lactis

Melatonin Suppository

BioPure’s Melatonin Suppository has 50mg of melatonin per suppository. As I discussed previously in my blog post on the Liposomal Melatonin product, melatonin is a key neurotransmitter in the body that helps to regulate and support our sleep cycles and circadian rhythm. Because this formula delivers the 50mg directly to the lower GI tract, there can be an impactful effect. Along with promoting healthy sleep cycles, melatonin also encourages nightly cellular repair and a healthy response to oxidative stress. This is by far one of our most trusted and used formulas. 

Reviews for Melatonin Suppository

Susan F used the Melatonin Suppositories and said:

“As a menopausal woman, I have come to value a night of good rest. This was recommended by my nutritionist. It helps me sleep deeper. I do still wake up in the middle of the night but I am able to get back to sleep quickly. I wake up feeling rested and have energy throughout the day.”

Nexus Suppository

The Nexus Suppository formula has a natural antioxidant property through its use of Artemisinin and Garlic. BioPure uses the powders in their Freeze Dried Garlic and Artemisinin formulas to make this suppository, along with the Cocoa Butter. 

Artemisinin powder provides a broad spectrum of microbial balance support. Artemisia annu is used in traditional Chinese medicine for inflammation and fevers. The garlic powder supports the balance of microbes as well. Garlic has been used for immune system support and antibiotic properties as well. 

Reviews for Nexus Suppositories

Izabela L. purchased the Nexus Suppositories and said: 

“This product is just amazing! I use it daily at night together with Skorpios suppositories for better detox effects. It is expensive but is worth every penny. I recommend it to anybody who struggles with parasites.”

Idalia Suppository

The Idalia Suppository formula is based on a variety of oils. The oils in this formula include Artemisia Essential Oil, Clove Essential Oil, Organic Cocoa Butter, Ozonated Organic Castor Oil, Ozonated Organic Olive Oil, and Walnut Oil. These oils support skin health, from microbial balance to resiliency and overall health. Ozonated Organic Olive Oil, for example, is rich in vitamins A, D, E, and K. These four vitamins can provide a variety of supportive properties to your skin and tissues. 

Skorpios Suppositories

Skorpios Suppositories deliver an innovative source of Calcium EDTA which binds with heavy metals in the body. The heavy metals that Calcium EDTA can bind to are chromium, iron, lead, mercury, copper, aluminum, nickel, zinc, calcium, cobalt, manganese, and magnesium. Calcium EDTA can assist in treating lead poisoning, but there is also a more general use for removing trace metals in the body.

Reviews for Skorpios Suppositories

Izabela L. also said:

“I have been using Skorpios suppositories for the consecutive 4 months so far. Very effective yet gentle product for detoxification and parasite elimination. I combine it with Idalia or Alta for a synergistic effect.”

Altheas Suppositories

The primary ingredient in the Altheas Suppositories is Green Coffee beans. These coffee plants are an excellent source of phenols called “chlorogenic acids” (CGA) which protect against oxidative stress. Studies have reported that CGA supplementation can improve damages caused by oxidative stress. There is 1% of caffeine per suppository, so these are not caffeine-free.

If you’re interested in reading further about CGA supplementation and the benefits it holds, check out this study on the effects of green coffee extract supplementation on lipid profiles.

Reviews for Altheas Suppositories

Rita W. purchased the Altheas Suppositories on our site and said:

“Super and works well!”


What are suppositories used for?

Suppositories are an innovative way to deliver nutrients and other ingredients to your body by bypassing digestion. This can create an opportunity for fast-acting effects. Suppositories can work faster than regular oral medications because suppositories melt inside the body once inserted and go directly into the bloodstream. If you have a history of GI conditions, it may be wise to speak with a healthcare professional prior to using a suppository, as the conditions affecting the GI tract may make the effectiveness of the suppository decrease.   

What happens to a suppository once inserted?

It takes anywhere from 5-20 minutes to fully dissolve and for the botanical ingredients to enter your bloodstream. 

How long do suppositories take to dissolve?

Most suppositories take 10-15 minutes to dissolve. However, some can take longer. I usually recommend sitting or laying down for 15 minutes to give it time to dissolve. Laying still allows the suppository to better dissolve in your body. 

What to do after inserting a suppository?

Lying down is the best idea so that gravity doesn’t work against you.  If you are going to be up and moving around, be aware that there may be leakage .   

How long should you keep a suppository in?

Try and keep the suppository in for the 15-20 minutes it takes to completely dissolve. If you’re feeling it come out, that means that it was not inserted high enough. 

How far do you push a suppository?

For adults, a suppository should be pushed about 3 inches into the rectum. For BioPure suppositories, there are insertion instructions included in each package. 

Why is my suppository melting?

I recommend keeping the suppositories in the fridge 45 minutes before use to ensure they stay firm and in their original shape and to make insertion easier. 

Can I leave a suppository overnight?

Yes, you can leave a suppository overnight.  You may want to use a towel or pad to soak up any leaks as you sleep.  

What is the side effect of suppositories?

There are not any dangers of using a suppository if inserted correctly. The ingredients in the BioPure suppositories are very strong and I recommend starting to use them slowly. Either break the suppository in half or use one every other day for a week. 

Concluding Thoughts

I consider suppositories “next level” solutions for complicated illnesses.  It seems that the more severe an illness, the more intense the intervention. 

Suppositories can be great alternatives for those who have difficulties taking oral medications. Important things to keep in mind include proper insertion according to the instructions provided by BioPure in each package. If you are curious about how any of these formulas can add benefit to your supplement regime, Schedule a consult with me, Carly Neubert BA, NC.