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HiPhenolic is Fantastic for Weight Loss and Blood Pressure

by Carly Neubert, BA, NC on June 19, 2024

Weight loss is a necessity for anyone with high blood pressure, diabetes, non-alcoholic fatty liver disease (NAFLD), or metabolic syndromes. Ozempic may be popular for the stars who want to lose a few pounds, but semaglutide medications are intended to address real and life-threatening disorders including obesity.  

Obesity is often coupled with high triglycerides, high blood pressure and heart disease.  Besides a healthy diet and lifestyle, polyphenols offer a natural solution to both weight loss and high blood pressure.  

HiPhenolic is a powerful blend of polyphenol extracts proven to support weight loss by activating AMPK.  These powerful enzymes signal your body to burn fat instead of storing it as cholesterol, triglycerides, or body fat.  For those with Metabolic Syndrome, or diabetes and high blood pressure, I recommend HiPhenolic in combination with HepatoCORE.  A 2-month trial of these  plant formulas is known as the poor man’s Ozempic and will support your health weight loss and heart health. 

Ortho Molecular rolled out a new supplement and it has the potential to make big waves in the supplement world. Why? HiPhenolic by Ortho Molecular focuses on Cardiovascular health by helping maintain healthy blood pressure levels, but it also goes a step further by helping increase satiety hormones and decrease hunger hormones.

Maintaining blood pressure levels is not something to be taken lightly, blood pressure fluctuations cause a variety of cardiovascular challenges. These fluctuations are a widespread struggle and can lead to serious health complications down the road. There are some traditional therapies available but they are largely not well tolerated. The optimal solution to maintain blood pressure levels within the normal range is to be intentional about diet and lifestyle changes. This can be a daunting task. Ortho Molecular has put together a nutrient formula that pulls the benefits from these changes and places them in a capsule that can help you in your journey. 

HiPhenolic users have seen more stable blood pressure levels, and even weight loss. How does that work? Why does that work? When we understand a bit more about how our bodies work, supporting them becomes that much easier, so let’s break it down to the basics! 

What are phytochemicals and what do they do?

Phytochemicals are also known as phytonutrients.  Polyphenols, like those in HiPhenolic, are a type of phytonutrient.  These are essentially chemical compounds found in plants that provide health benefits to your body. These compounds are rich in antioxidant and anti-inflammatory properties. In today’s blog we’ll focus on the antioxidants. Antioxidants are mighty warriors! Antioxidants fight free radicals, which are unstable molecules that build up and start to damage your cells. Antioxidants mitigate that damage. This is important because as cells become more damaged, we start to see oxidative stress in the body which can eventually lead to a slew of symptoms and diagnoses.

Phytonutrients have fascinated scientists and led to further study of the potential benefits to the human body. Ortho Molecular’s HiPhenolic uses a type of Phytonutrient called a Polyphenol. Polyphenols are rich in the antioxidants we talked about earlier. That being said, HiPhenolic is not a hodge-podge of random plants, the polyphenols that are found in this supplement have been carefully chosen based on studies of their efficacy. 

Polyphenols are nature’s way of turning on an important fat-burning enzyme and support normal blood pressure. 

AMPK: The “On” switch for burning fat 

We all know that to lose weight we must burn off extra body fat.  But how do we tell our bodies to burn that stubborn belly fat? The key to turning on “fat burning” is an enzyme named adenosine 5’ monophosphate-activated protein kinase or AMPK for short.

Our bodies make this enzyme and there are 5 ways to increase it: 

  1. Exercise 
  2. Supplements and medications 
  3. Specific polyphenols found in plant foods
  4. Fasting
  5. Exposure to cold temperatures (cold plunge or cryotherapy)


AMPK, the fat burning enzyme is activated in relationship to how hard you are exercising.  If you are taking a gentle walk, very little AMPK will be activated and you will not burn much fat.  Intense aerobic exercise, with an elevated heart rate, will activate more AMPK and result in more fat burned during exercise.  

Polyphenol Antioxidants in Supplements 

Polyphenols are antioxidants found in many plant foods. You can take polyphenol extracts in supplement form to support weight loss and blood pressure.  

Hiphenolic is a polyphenol blend with ingredients that have been proven to support weight loss metabolism and normal blood pressure.

Metabolaid (Hibiscus and Lemon Verbena)

One of the most interesting ingredients in HiPhenolic is Ortho Molecular’s Metabolaid®. This is a unique blend made up of Hibiscus and Lemon Verbena extract. Lemon Verbena has been used in a wide variety of contexts ranging from being a food spice, to a cosmetic, as well as in traditional formulas in South America and Southern Europe. Hibiscus flower has been used in teas as part of traditional Chinese formulations to help maintain normal blood pressure levels and keep inflammation at bay. Scientists have found that combining the polyphenols from both Lemon Verbena and Hibiscus results in even stronger benefits as they interact and activate one another to promote optimal metabolic efficiency. In 2018, a double-blind, placebo-controlled and randomized trial studying this powerful duo took place. 56 subjects who had challenges with weight management were given this polyphenol combination and showed significant improvement in body weight, abdominal circumference, and body fat percentage. The conclusion of this study included the following statement, “this polyphenolic combination may be used for weight management by increasing long-term weight loss maintenance through the modulation of appetite biomarkers”. Essentially, this combination will help combat the yo-yo dieting that happens with intense calorie deficits as this blend addresses appetite and in turn could help avoid the weight regain period that tends to come after caloric restriction. 

Green Coffee Beans

Joining the HiPhenolic ingredients team, green coffee beans have naturally high levels of chlorogenic acid which is yet another polyphenol. This polyphenol is included because of its powerful antioxidant properties. Unroasted and decaffeinated, the green coffee bean extract in HiPhenolic can provide maximized benefits of chlorogenic acid. Analyses of trials including this fascinating extract have shown a benefit in blood pressure level maintenance, maintaining optimal lipid markers, better metabolism, decreased body weight, and better appetite scores among other things. This helps further the goals of HiPhenolic on all levels. There is ZERO caffeine content in Green Coffee Bean extract so you will not end up with the caffeine jitters or the slump afterward.


And last, but certainly not least, magnesium joins the HiPhenolic crew. Magnesium is a key resource for the body; used in protein synthesis, blood glucose control, and regulation of blood pressure. Overall, magnesium citrate supplementation has proved helpful in maintaining healthy blood pressure and blood sugar levels. This makes magnesium a no-brainer addition. Magnesium can be linked to hundreds of symptoms and diseases. The pioneering work of Dr. Carolyn Dean has shown us the evidence for the need to supplement with magnesium. All of these ingredients have been studied for their benefits and are utilized in ways that maximize their potential.  

Polyphenol Antioxidants in Foods 

Foods high in polyphenol antioxidants will flip on the AMPK switch and signal your body to burn fat.  The foods with the highest amount of AMPK-activating polyphenol antioxidants are: 

  • Grapefruit
  • Olive oil
  • Garlic 
  • Onions
  • Fresh leafy greens, broccoli, artichokes and green beans
  • Green and other teas 
  • Berries, like blueberries, blackberries, raspberries, bilberries, etc.
  • Grapes
  • Pomegranate
  • Apples
  • Cinnamon
  • Turmeric
  • Pecans


Studies show that as little as a 6-hour fast can increase your body's AMPK and fat burning. I recommend a 13-hour fast every night to increase AMPK as well as induce healthy changes in your microbiome and autophagy.  

Fasting can increase AMPK. Intermittent fasting or a time-restricted eating window will activate AMPK and signal your body to burn fat. This can be challenging, or nearly impossible if you are struggling with cravings or the high and low blood sugar of diabetes or pre-diabetes.  As a starting point, try fasting from 6pm to 7am the next morning.

Your ability to fast is controlled by your blood sugar, adrenal glands, and the lifestyle choices you make. Some people experience dizziness, fatigue, and headaches from fasting. These are signs that you may be dehydrated and your metabolism is struggling to move from sugar-burning to fat-burning.  Drink plenty of water and add NO SUGAR electrolytes if necessary.  If you consume electrolyte powder with sugar, you will have broken your fast and activated your insulin response. 

Exposure to cold temperatures (cold plunge or cryotherapy)

Animal studies show that exposure to cold will increase fat burning. A 2021 study showed that young men who did cold plunges had more brown (good) fat and less white (bad) fat than those who did not.


Where can I get polyphenols that will increase fat burning?

Many foods contain polyphenols that will activate AMPK fat-burning enzyme.  If you already have high blood pressure and excess weight, a concentrated polyphenol supplement will expedite your results. 

What activates AMPK for more fat-burning and weight loss? 

AMPK can be activated by many foods exercise, supplements, fasting, and cold exposure. 

What is the strongest activator of AMPK?

Exercise is the fastest activator of AMPK.  The more vigorous your exercise, the more AMPK is activated for fat burning. 

What foods are high in AMPK?

Many foods, listed above, are high in polyphenols and will activate AMPK. 

How can you trick your body into burning fat?

AMPK is known as the master metabolic enzyme and largely controls fat-burning and weight loss.   

How can I increase my AMPK levels naturally?

Eating foods high in polyphenol antioxidants, taking polyphenol supplement formulas, exercising, fasting, and cold exposure will naturally increase AMPK for more fat-burning and weight loss. 

Does HiPhenolic really work?

Yes, the ingredients in HiPhenolic have been proven to reduce weight and decrease blood pressure.  Medical studies are listed below. 

What is HiPhenolic used for?

HiPhenolic is used for people with diabetes and high blood pressure.  I recommend it in combination with HepatoCORE for a 60-day regimen. 

What is HiPhenolic supplement?  

HiPhenolic is a polyphenol antioxidant supplement formula designed to support your body in healthy weight loss and normal blood pressure. The ingredients are proven to decrease blood pressure and activate AMPK, the master fat-burning enzyme.

How do you take HiPhenolic?

Take 2 capsules per day with or without food. If you want to accelerate weight loss and overcome cravings, I recommend adding in HepatoCORE for recommend 90 day or 3 month supply because the studies took place over 90 days.  

How can I lower my blood pressure naturally?

Magnesium and adequate hydration with water are the easiest and quickest ways to decrease blood pressure.  

Why are Ortho Molecular products so expensive?

Ortho Molecular supplements are scientifically formulated by medical experts and use only the highest quality and tested raw materials.  The formulas are manufactured in a cGMP and laboratory-tested facility to ensure purity in ingredients and finished products. OrthoMolecular bases their formulas and doses on medical studies and cutting-edge research. 

Concluding Thoughts

Ortho Molecular’s HiPhenolic may sound complex at first glance, but at its core it’s rather simple. Ortho Molecular has taken a close look at the power of plants; they have found ways to bring out the best that each plant has to offer. With that knowledge, they’ve equipped their supplement with maximum benefits. If you would like a personalized plan for using HiPhenolic in your wellness journey, or want to learn more about how to support your metabolic activity, blood pressure levels and cardiovascular health, Schedule a consult with me, Carly Neubert BA, NC.

Sources Used

  1. https://health.clevelandclinic.org/polyphenols/#:~:text=Polyphenols%20are%20nutrients%20in%20plants,that%20provide%20specific%20health%20benefits.
  2. https://www.nal.usda.gov/human-nutrition-and-food-safety/food-composition/phytonutrients#:~:text=What%20are%20Phytonutrients%3F,health%20benefits%20to%20the%20body.
  3. https://www.webmd.com/diet/foods-high-in-polyphenols
  4. https://pubmed.ncbi.nlm.nih.gov/29862395/
  5. https://www.orthomolecularproducts.com/docs/default-source/pdn/ompi-hiphenolic_pdn-a-draft1.pdf?sfvrsn=e10785ff_10

Studies for Green Coffee Extract and High Blood Pressure and Weight Loss 

  1. Suzuki A, Kagawa D, Ochiai R, Tokimitsu I, Saito I. Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. Hypertens Res. 2002;25(1):99-107.

  2. Gibbs J, Gaskin E, Ji C, Miller MA, Cappuccio FP. The effect of plant-based dietary patterns on blood pressure: a systematic review and meta-analysis of controlled intervention trials. J Hypertens. 2021;39(1):23-37.

  3. Han B, Nazary-Vannani A, Talaei S, et al. The effect of green coffee extract supplementation on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2019;33(11):2918-2926.
  4. Haidari F, Samadi M, Mohammadshahi M, Jalali MT, Engali KA. Energy restriction combined with green coffee bean extract affects serum adipocytokines and the body composition in obese women. Asia Pac J Clin Nutr. 2017;26(6):1048-1054. 
  5.  Roshan H, Nikpayam O, Sedaghat M, Sohrab G. Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: a randomised clinical trial. Br J Nutr. 2018;119(3):250-258.

  6. Pourmasoumi M, Hadi A, Marx W, Najafgholizadeh A, Kaur S, Sahebkar A. The Effect of Green Coffee Bean Extract on Cardiovascular Risk Factors: A Systematic Review and Meta-analysis. Adv Exp Med Biol. 2021;1328:323-345.

Studies on MetabolAid Hibiscus and Lemon Verbena for weight loss 

  1. Boix-Castejón M, Herranz-López M, Gago AP, et al. Correction: Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food Funct. 2018;9(7):4037. 
  2. Herranz-López M, Olivares-Vicente M, Boix-Castejón M, et al. Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/ obese subjects: A randomized controlled trial. Sci Rep. 2019;9(1):2999. Published 2019 Feb 28. 

Studies on magnesium and blood pressure and weight loss 

  1. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington (DC): National Academies Press (US); 1997. 
  2. Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37.
  3.  Rude RK. Magnesium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, Mass: Lippincott Williams & Wilkins; 2012:159-75. 
  4.  Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. 
  5.  Afitska K, Clavel J, Kisters K, Vormann J, Werner T. Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome: a 12-week, placebo-controlled, double-blinded pilot trial. Magnes Res. 2021;34(3):130-139