Metagenics for Gut Health: The Best Formulas for Healing and Repair

Metagenics is a high-quality, professional-grade supplement brand that offers unique formulas. Their research is often forward-thinking and cutting-edge.  Often, Metagenics is the first to market, with other supplement companies following their lead.   The SPM Active was the first supplement of its kind when Metagenics introduced it in 2017.  Since then, many additional companies have followed their lead with specialized fish oil supplements.  They were the first company to offer medical foods tailored to specific conditions and symptoms.  They use GMP (good manufacturing practices) and 3rd party testing for their raw ingredients.  Their medical advisory board has included well-known thought leaders such as Dr. Sara Gottfried, Dr. Jeffrey Bland, and Dr. Mark Houston. 

Originally founded by the Katke family in 1983, Metagenics has continued to focus on science to lead the way in formulating its supplements.  The original mission statement was “Genetic Potential Through Nutrition” and is now “Science you can feel.”  

They have literally pioneered the way for medical foods that are much more potent than an ordinary protein powder.  The UltraInflamX line of medical food powders supports colitis, Crohn’s disease, diabetes, syndrome X, metabolic syndrome, leaky gut, IBS, and food sensitivities.  Along with their Zinlori 75, UltraInflamX Plus 360 is a winning solution for an H. pylori infection and the symptoms that accompany it. 

For gut issues not linked to H. pylori, I recommend food sensitivities testing, an elimination diet, and a protocol designed to support cellular healing. Glutagenics is a foundational formula for any gut-healing protocol and is a powerful addition to the UltraInflamX medical foods.   

Stress plays a huge role in digestive disorders.  Recent research, including a study from Monash in 2020, emphasizes the critical need for stress management to alleviate digestive symptoms.  Here are some tips for managing stress and reducing digestive symptoms: 

1. Eat slowly and chew your food at least 30 times per bite.  This allows your central nervous system and vagus nerve to come into a parasympathetic (rest and digest) mode instead of being in stress (fight or flight mode)
2. Sit/rest for 5 minutes after finishing a meal.  Nerva is  an app that teaches you to visualize and relax after eating.  
3. Consider DBT, CBT, or IFS therapy surrounding food habits or digestive symptoms 

Here is my top Metagenics formula for managing the physical effects and HPA-axis of stress and the accompanying hormones and body chemicals. 

Along with the other blogs I have written (linked above), here are highlights from some of their outstanding formulas: 

UltraInflamX Plus 360°

UltraInflamX Plus 360  is an advanced medical-food formula designed to provide targeted nutritional support for individuals with compromised gut function, especially those managing inflammatory bowel conditions like Ulcerative Colitis and Crohn’s disease. I recommend this over GI Sustain and GI Replenish when I have clients with more severe symptoms, or if they have a clinical diagnosis of IBS, Crohn’s, Ulcerative colitis, or IBD.  UltraInflamX can be used in conjunction with GI Sustain or GI Replenish.

It is clinically formulated by the Metagenics medical advisory board.  UltraInflamX is more than a meal replacement or protein powder.  It is designed to deliver therapeutic macro- and micro nutrients and to  help address the distinct needs of gastrointestinal wellness and nutrient absorption challenges often associated with inflammatory bowel disease. 

The ingredients in UltraInflamX Plus 360 that are medically studied are: a patented blend of curcumin and fenugreek which has been engineered to improve bioavailability.  These ingredients support a balanced inflammatory response and promote digestive comfort. Those dealing with severe or chronic digestive symptoms can be reactive to many food and ingredients.  The protein includes a highly digestible pea/rice base with added essential amino acids. The additional vitamin/mineral blend, and phytonutrients are included to nourish intestinal mucosal cells and support overall gut integrity.

UltraInflamX Plus 360 is intended to be mixed with water, although you can mix it with any liquid of your choice.  I recommend starting with water and adding other ingredients as tolerated. Here are a few ingredients I recommend:

1. Full-fat coconut milk
2. MCT oil (as tolerated)
3. Avocado
4. Fresh/frozen berries 
5. Fiber (as tolerated) such as chia, flax, or psyllium
6. Hemp seeds

UltraInflamX Plus 360 is available in pineapple banana, chocolate orange, mango, original spice, and orange.  You can purchase it in a 14 or 30 serving bag.  The most popular flavor among my clients is UltraInflamx Plus 360 Chocolate Orange.

Carly recommends this for: 1-2 servings per day for clients who have a diagnosis of IBD, IBS, Ulcerative colitis, Crohn’s disease, or any other condition causing malabsorption. 

Clear Change 10-Day Detox Program (Vanilla)

The Clear Change 10-Day Detox Program is a comprehensive metabolic detoxification regimen designed to support your body’s natural cleansing pathways while maintaining energy and daily function. 

Clear Change Detox Program is designed for an occasional “spring cleaning” or seasonal reset.  The contents of the kit are:

1. UltraClear® RENEW Detox Powder
2. AdvaClear 
3. Shaker bottle for mixing detox protein powder 
4. Program guide including meal plans and recipes

This program combines targeted nutritional support with an easy-to-follow plan to help enhance Phase I and II liver detoxification processes.  The main ingredients in UltraClear® RENEW Detox Powder are a specialized blend of antioxidants, vitamins, minerals, and phytonutrients that support liver function, alkalinization, and healthy elimination with a low-allergy rice protein base. This formula helps fuel daily activities and encourages balanced detox pathways without the fatigue associated with restrictive cleanses. 

UltraClear® Renew Detox Powder is included in the kit and can also be used as a stand alone formula for long-term use.  

The kit also includes AdvaClear capsules, which provide methylated B-vitamins and ingredients that support liver enzyme activity and antioxidant protection throughout your 10-day detox process. 

This program is a favorite for the new year when everyone is recovering from indulging over the holidays.  I also recommend this program directly following winter as spring arrives.  

The Clear Change Program is available in a 10 day kit or a 28 day kit.  You can choose between chai, vanilla, and berry flavors. 

Carly recommends this for: a seasonal detox 2-4 times per year; I recommend pairing this with 1 serving of UltraInflamX Plus 360 if you are concerned about getting enough calories or dealing with digestive symptoms.  

CoQ10 ST - 200 mg

CoQ10 ST®-200 mg is a high-quality supplement formulated to support cardiovascular health CoQ10 is an important enzyme that plays a vital role in heart muscle function and overall cardiovascular wellness.  Each softgel delivers 200 mg of coenzyme Q10 (ubiquinone)—a nutrient the body uses to produce energy at the cellular level.  When shopping for CoQ10, please look for the activated form ubiquinone so that you can achieve the results you are looking for.  

CoQ10 is known for its ability to support healthy blood pressure that’s already within the normal range, and its antioxidant properties help protect cells from oxidative stress. This formula also includes vitamin E, which provides additional antioxidant support to help defend against free radicals and support overall cellular health. 

Its softgel form ensures stability and absorption, making it a trusted choice for individuals seeking science-backed support for heart and metabolic health.

Long term research has proven that statin drugs such as Lipitor, Crestor, Zocor, or Prevachol deplete your body of CoQ10.  This is the most likely cause of muscle weakness and wasting for those on statin drugs.  The best food source of CoQ10 is red meat which is often taken out of the diet when cholesterol is deemed to high.  So reducing red meat intake and taking a statin drug is a double whammy for your body’s ability to make CoQ10.  

Common generic statin drugs:

1. Atorvastatin
2. Rosuvastatin
3. Simvastatin
4. Pravastatin

Carly recommends this for: clients with cardiovascular symptoms associated with Long-covid or those taking statin drugs due to high cholesterol.  I also recommend for those with diabetes or metabolic syndrome or high blood pressure.    

UltraMeal Advanced Protein (French Vanilla)

UltraMeal® Advanced Protein is a medically formulated nutritional shake designed to support the management of sarcopenia which is age-associated loss of skeletal muscle mass that can begin as early as age 30.  Sarcopenia can also result from long-term illness or hospitalization.  I recommend this protein-based medical food for those in rehabilitation centers or who are actively receiving physical therapy.  

This advanced protein powder is crafted to help maintain muscle integrity by delivering up to 21 g of protein per serving from a proprietary blend of pea and rice proteins.  Both of these proteins are low allergenic and less likely to cause food sensitivity reactions.  They are combined with essential amino acids that are critical for muscle retention and synthesis. The formula also includes a robust micronutrient profile with 25 vitamins and minerals to support protein utilization, metabolic function, and healthy body systems.  It is a convenient and nutritionally balanced option for those seeking to maintain strength and functional capacity. With a smooth French vanilla flavor, this shake can be blended into water or other approved liquids, fitting easily into daily routines. 

Top ingredients to add to UltraMeal Advanced:

1. Cacao powder
2. Hemp seeds
3. Bananas
4. Macadamia nuts (blended)

Carly recommends this for: clients who are losing muscle mass due to age or illness.  I also recommend using it alongside Bone Builder for bone health. 

I discuss Leaky Gut and IBS in this blog. GI Sustain and UltraGI Replenish are the best choices for a medical food when you are dealing with these symptoms:

1. Alternating diarrhea and constipation
2. Bloating after meals
3. Gas/burping following a meal
4. Fatigue following a meal
5. Brain fog following a meal

Vitamin D3 5000

Vitamin D3 5000 delivers a high-potency dose of 5,000 IU of cholecalciferol.  This is the most bioavailable form of vitamin D.  It comes in easy-to-swallow softgels to help support optimal bone strength, immune function, and overall wellness. Besides supporting your immune system, Vitamin D plays a central role in calcium absorption, which is essential for maintaining strong bones and teeth.  Daily supplementation with a potent dose like 5,000 IU can be especially beneficial for individuals with low sun exposure or those seeking to optimize their vitamin D status alongside a balanced health plan. Even those living in a warm area, like Arizona, may be covering their skin and impeding their ability to manufacture vitamin D through their skin.  This formula offers a convenient and consistent way to help maintain healthy vitamin D levels year-round.  Vitamin D testing is simple and can be included in a routine blood draw.  You can also order your own kit at home and use just a single drop of blood.  

Vitamin D is best absorbed with fat, so choose a supplement, like this one, that is mixed with a healthy fat.  Always take vitamin D supplements with a meal for best absorption. 

Carly recommends this for: clients with immune dysfunction and as a general supplement for everyone to consider. 

PhytoMulti Multivitamin

PhytoMulti® Multivitamin is a comprehensive daily multivitamin tablet designed to support overall wellness.   The nutrients support multiple body systems with a single, convenient formula. The formula is inspired by principles of the Mediterranean diet, and it provides a broad array of essential vitamins and minerals alongside an advanced phytonutrient blend that includes 13 plant-derived extracts such as rosemary, green tea, turmeric, and citrus bioflavonoids to help support antioxidant activity and cellular protection. This multivitamin helps fill nutritional gaps, supports key functions like energy production, immune health, digestion, brain support, and liver function, and contributes to healthy aging and whole-body balance. With methylated B vitamins for enhanced bioavailability, plus zinc, selenium, and vitamin C working synergistically to support immune defenses and antioxidant protection.  

For those of you who need a specialized multi-vitamin, I recommend Metagenics Wellness Essentials.  This includes the Phytomulti plus additional nutrients for aging men and women. Read more about the important nutrients that support aging, hormones, and joints in the blog linked above.  

Carly recommends this for: clients who have had a poor diet, malabsorption due to digestive illness, or do not eat vegetables at every meal.  

Conclusion

Metagenics is a time-tested and science-verified company that provides you with the tools to improve your health.  If you would like a personalized plan for implementing these formulas into your routine, schedule a consult with me, Carly Neubert BA, NC.