Grape Pips contain flavonol proanthocyanidin extract from grape seeds, which provides powerful antioxidant activity against peroxyl free radicals, and supports capillary integrity.* Our high-quality raw material contains not less than 95% total polyphenols including 83% oligomeric proanthocyanidins. Grape seed proanthocyanidins were originally discovered and patented by the same researcher who discovered pycnogenol in pine bark extract and is the main phenolic antioxidants found in red wine. They have undergone extensive clinical and toxicological studies, and exhibit powerful antioxidant activity, due to their diphenol components and related structures.*
|Serving Size: 3 Capsules||Amount Per Serving|
|Grape Seed Extract (95% total polyphenols including 83% oligomeric proanthocyanidins)||300 mg|
Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, L-leucine.
As a dietary supplement, 1-3 capsules one to three times daily with meals, or as directed by a healthcare practitioner.
Proanthocyanidins are the most powerful antioxidants found in wine and in grape seeds, specifically targeting their interactions with peroxyl radicals, due to the hydrogen transfer mechanism involved in the radical-scavenging reaction. They can inhibit the peroxidation of ingested lipids during the digestive process, preventing them from being oxidatively degraded before they have a chance to get into the bloodstream.*
In studies that supplemented meals with grape seed proanthocyanidins, a significant reduction of postprandial plasma oxidative stress was shown.* In one study, volunteers ate the same test meal containing an abundance of oxidized and oxidizable lipids without (control) or with 300 mg of grape seed extract (GSE), containing proanthocyanidins. Postprandial concentration of plasma lipid hydroperoxides increased only in the control group, and postprandial plasma antioxidant capacity increased only in the GSE supplemented group.* Also, LDL showed increased susceptibility to oxidation following the control meal, but less susceptibility to oxidation following the GSE supplemented meal.* Overall, these results strongly suggest that taking GSE with a meal can significantly enhance resistance to oxidative modification of LDL.* Other studies show that even with a high cholesterol diet, proanthocyanidins can inhibit lipid-laden foam cell deposition.* Still other studies show that proanthocyanidin flavonoids may support the integrity of collagen structures and the capillaries.*
Because they can have a powerful effect on the digestive tract, the antioxidant effectiveness of proanthocyanidins is not dependent on bioavailability. However, with their superior water solubility, they are easily absorbed and are generally well tolerated.