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Ortho Molecular
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Endocrine HealthÂ
Melatonin plays a key role in regulating the body's circadian rhythm. Melatonin can be helpful in regulating sleep cycles in individuals who have irregular sleep patterns.
Melatonin is produced primarily in the pineal gland but also in the bone marrow, platelets, GI tract, eyes, skin, and lymphocytes. Its chemical precursor is serotonin, a neurotransmitter derived from tryptophan. Serotonin must be acetylated and methylated to form melatonin. Synthesis and production of melatonin is affected by light exposure to the eyes; serum concentrations of melatonin are typically low during the day hours and increase when dark. Since it has important effects on circadian rhythms, melatonin has been reported to have significant effects on sleep-wake cycles and antioxidant function.
Key Benefits and Features:Â
| Serving Size: 1 Tablet | Amount/Serving |
| Melatonin | 1 mg |
Other Ingredients: Isomalt, Natural Cane Sugar, Croscarmellose Sodium, Sodium Stearyl Fumarate, Stearic Acid, and Silicon Dioxide.Â
Does Not Contain: Gluten, yeast, artificial colors, or flavors.Â
Take 1 tablet per day or as recommended by your health care professional.
Warning: If you are pregnant or nursing, consult your physician before taking this product. Keep out of the reach of children.Â
Storage: Keep tightly closed in a cool, dry place.Â
Deficiency
Nighttime secretion of melatonin is at its highest during childhood and decreases over time. Research suggests that melatonin supplements support healthy sleep patterns in certain individuals, such as the elderly, individuals with nighttime working hours, or people traveling across time zones. Low levels of melatonin in the body are often associated with sleep disturbances.
Sleep Support
Melatonin supports the quality of healthy sleep as it relates to falling asleep, sleep efficiency, and awakening. In adults, studies have shown that doses between 0.3-75 mg have a positive effect on increasing total sleep time and reducing the time it takes to fall asleep. Two studies using 5 mg of melatonin in adults with delayed sleep found the melatonin shortened the time it took to fall asleep by 82 minutes and 115 minutes in the first and second studies.
A study of subjects who took melatonin for one week had better initiation, maintenance, efficacy, and activity of sleep when compared to placebo. Another randomized, double-blind, placebo-controlled study of 33 subjects found melatonin to support the onset, quality, depth, and length of sleep without daytime sleepiness. Finally, a review of 10 trials suggests that melatonin supplementation also helps support sleep patterns in individuals crossing time zones.
Antioxidant Support
Melatonin has been shown to be a powerful antioxidant inducer. Â It supports glutathione production and stimulates intracellular antioxidant enzyme production, including superoxide dismutase and glutathione peroxidase. It has also been found to scavenge free radicals and promote cytokine balance, which helps maintain normal inflammatory balance. Melatonin is also able to pass through the lipid part of low-density lipoprotein (LDL) and act as an antioxidant in cells. It has also been found to maintain healthy blood pressure levels.
