A recent University of Houston study has shown low dose malic acid is virtually ineffective at helping reoxygenation of tissue, while high doses were of significant benefit.
Malic Acid is a key metabolite in the Krebs cycle. It is important for maintaining energy within muscle tissue, especially when tissue oxygen levels are depleted. The relationship between low tissue oxygen and malic acid have been shown in both animal and human studies, where improvements were seen with oral supplementation. Successful human clinical trials combined malic acid with magnesium.