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Probiotic for Oral Microbiome Support
ProbioMax® Oral is a chewable probiotic solution for a healthy smile. It features the HN019 strain of Bifidobacterium animalis subsp lactis (B lactis) provided in a CSP™ Screw Cap Bottle with 3-Phase Activ-Polymer™ Technology for optimal freshness. The use of B lactis HN019 to colonize the mouth naturally supports the oral environment, including teeth and gums, and is an excellent supplement to standard dental care.
Clinical Applications
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Serving Size: 1 Chewable Tablet |
Amount/Serving |
| Bifidobacterium lactis HN019S1 | 3 mg (1 Billion CFU†) |
Other Ingredients:Xylitol, mannitol, hydroxypropyl cellulose, stearic acid, citric acid, magnesium stearate, natural flavors (no MSG), silica, malic acid, and stevia leaf extract.
Formulated to Exclude: Wheat, gluten, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.
S1. HN019™ is a trademark of the Fonterra Group of companies used under license.
† Colony-Forming Unit
Take one chewable tablet twice daily (after waking up and before bedtime), or use as directed by your healthcare professional.
Consult your healthcare professional before use. Individuals taking medication should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged.
Keep tightly closed in a cool, dry place out of reach of children.
The oral cavity harbors the second-largest microbiome in the human body, comprising a diverse range of microorganisms. A healthy and diverse oral microbiome is critical for commensal−host homeostasis and is associated with periodontal health. Several factors, including poor oral hygiene, an unhealthy diet, tobacco and alcohol use, loss of beneficial microorganisms and microbial diversity, or increased pathogens, may cause oral microbiota dysbiosis. This imbalance precedes the organization of microbes and toxins into dysbiotic microbial biofilms (dental plaque). These biofilms generate extracellular polysaccharides and aid in microbial aggregation and adhesion to oral surfaces, triggering host immune-inflammatory responses and jeopardizing periodontal tissues. Such changes in the oral environment can also increase opportunistic keystone pathogen activity like Porphyromonas gingivalis, which perpetuates dysbiosis and inflammation through further microbiome remodeling.
Oral microorganisms engage in dynamic interactions within the oral environment and with microbiota from other anatomical sites, such as the gut. Humans swallow approximately 600 mL of saliva daily, which contains mouth-derived microorganisms. Researchers postulate that pathogenic bacteria originating from the mouth reach the intestine, where they can disturb the intestinal microbiome, leading to changes in systemic immune function and cytokine production.2-5 This mouth−intestine connection emphasizes the importance of a healthy oral microbiome and environment. Probiotics can help address oral dysbiosis, dysbiotic biofilms, and their sequelae. They generally exert their effects by producing bactericidal bioactive peptides, acids that alter cellular pH, and other inhibitory substances. Probiotics can also compete with pathogens for nutrients and binding sites, including biofilm binding sites. Additionally, probiotics may enhance epithelial barrier function by influencing the host’s signaling pathways and immune-inflammatory responses. Probiotic Bifidobacterium strains are recognized for their ability to promote dental and gum health, modify periodontal biofilms, and regulate host immune-inflammatory responses. It is important to emphasize that outcomes depend on the strain, dose, delivery, and therapy duration. For these reasons, it is critical that probiotics for oral health reflect the clinical evidence.
Bifidobacterium animalis subsp lactis (B lactis) HN019
Bifidobacterium animalis subsp lactis (B lactis) HN019 is a probiotic strain originally isolated from yogurt and later commercialized as an ingredient for dietary supplements and health foods. Research and testing indicate that B lactis HN019 has excellent adherence to epithelial cells, a high tolerance for the stomach’s low pH environment, and a resistance to bile salts.2,8 These characteristics make it an excellent oral probiotic for human health. Furthermore, the complete genome sequence of B lactis HN019 was published in 2018. This level of identification allows for stringent control of product quality, safety, purity, and consistency. Abundant research substantiates the benefits of B lactis HN019 for human health, including research focused on its potential to support dental and gum health and improve oral microbiological and cytokine parameters.
