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Ultra Liver Support contains herbal and cruciferous ingredients to help support liver function and detoxification. This formula contains broccoli sprout extract standardized to sulforaphanes and Wasabia japonica containing ITCs to support phase II activity in the liver and activation of Nrf2 for detoxification.
Each serving contains:
Barberry Extract - 250 mg
(Berberis vulgaris, root and stem)
Dandelion (Taraxacum officinale, root) - 250 mg
Bilberry Extract - 200 mg
(Vaccinium myrtillus, fruit) (Standardized to provide 25% anthocyanidins)
Milk Thistle Extract - 175 mg
(Silybum marianum, fruit) (Standardize to provide 80% silymarin)
Artichoke Extract (Cynara scolymus, leaf) - 150 mg
Schisandra Extract - 150 mg
(Schisandra chinensis, fruit)
(Standardized to 2% schizandrins)
Broccoli Extract - 125 mg
(Brassica oleracea l., sprout)
(Standardized to 500 mcg of sulforaphane)
Wasabia japonica (rhizome) - 50 mg
(Providing 600 mcg of isothiocyanates)
Other ingredients: Hydroxypropyl methylcellulose (capsule), ascorbyl palmitate, silica, and cellulose.
As a dietary supplement, adults take 1 tablet 3 times daily or as directed by your healthcare professional.
Ultra Liver Support contains several dietary constituents that have been shown to support the function and structure of the liver. The liver is the primary detoxification site in the body regulating conversion of harmful by products to neutral compounds. A variety of cruciferous vegetables including broccoli and wasabi may have potent liver protective activities which include induction of a detoxifying enzyme, glutathione Stransferase (GST). The conversion of oxidized glutathione disulfide (GSSG) to its reduced state (GSH) is the body’s primary pathway for dealing with oxidative stress. This activity can be both liver protective and antiproliferative, likely via influencing levels of reactive oxygen species.
Broccoli sprout-derived sulforaphane is a phytochemical which has been shown through double-blind, placebo controlled human studies to be capable of activating GST. Sulforaphane is considered to be an inducer of phase II enzyme activity in the liver and has also demonstrated a role in maintaining healthy colon cell function. Another plant in the Brassicacea family containing phytochemicals with potential for cytoprotection is wasabi. The wasabi rhizome contains various isothiocyanates and in particular a key active compound called 6-methylsulfinylhexyl isothiocyanate (6-HITC) which has been shown to support various biological properties including the induction of nuclear factor erythroid 2-related factor 2 (Nrf2). Nutrigenomic activation of transcription factor Nrf2, is required to turn on many genes that induce cytoprotection such as those playing key roles redox status and detoxification.
Silybum marianum, milk thistle, is rich in flavonoids known collectively as silymarin. Silymarin has been shown to support and enhance normal, healthy liver function through three primary actions. By binding to the outer cell membrane, silymarin inhibits unwanted toxins from entering the cell. † Silymarin further protects the liver as an important component of the liver’s antioxidant defense. The liver generates potentially damaging, toxic free radicals and reactive oxygen species (e.g. peroxides) as a result of its normal metabolic and detoxifying functions. Silymarin supports healthy levels of glutathione and superoxide dismutase, two primary substances with antioxidant activity in the liver that reduce free radicals known to interfere with normal cell function.
Cynara scolymus, artichoke, has been used medicinally for centuries. Similar to milk thistle, it is beneficial to the liver as it supports the liver’s excretion of fats. Extracts of artichoke can stimulate the flow of bile from the liver and support liver cells from oxidative damage. Cynara’s usefulness in liver health is thought to be due to its content of caffeoylquinic acids, e.g. cynarin, and flavonoids.
Lipopolysaccharide (LPS) triggers excessive secretion of a variety of mediators including nitric oxide (NO) and prostaglandin E2 (PGE2). Luteolin and luteolin-7-O-glucoside, the active compounds with antioxidant activity from dandelion extract may support cellular protection and reduce lipopolysaccharides in animal models.† Barberry and bilberry extracts have high antioxidant activity to support the production of glutathione. Preclinical evidence on bilberry suggests protective effects on liver function by reduction in the levels of reactive oxygen species in stressed animals.
WARNING: This product can expose you to lead, which is known to the
State of California to cause birth defects or other reproductive harm. For
more information go to www.P65Warnings.ca.gov/food
