Enter Discount Code 10HEALTHY at checkout for $10 off orders of $100 or more! Brand exclusions apply - Click for details

Your Liver Loves The Lumbro': Give it Boluoke!

by Carly Neubert, BA, NC on July 20, 2022

About 296 millions people are currently living with Hepatitis B. The WHO (World Health Organization) estimates that 1.5 millions new infections will occur each year. Hepatitis B is a viral infection that attacks your liver tissue and causes long term health complications and can lead to death.

If you are like most people, you think of Hepatitis B as a sexually transmitted infection or disease that drug users get. While this may have some truth to it, Hepatitis B can be passed from a mother to a child during birth. 

Current treatments for Hepatitis B Virus (HBV) include oral antiviral medications, chemotherapy, and liver transplant.  

Complications caused by Hepatitis B Virus (HBV) are liver failure, liver cirrhosis, liver cancer, and hypercoagulation including deep vein thrombosis, pulmonary embolism, and myocardial infarction. In 2019, almost 1 million lives were lost to Hep B infections and complications.   

While there is no known cure for Hep B, there are many supportive strategies.  One that might surprise you is the use of lumbrokinase enzymes. In 2020, a study showed that lumbrokinase supplements may stop the replication of Hep B in cells. This study was performed in-vitro, which means in petri dish, and in-vivo, which means in a living organism. In this case, the study was performed on mice.  

Two additional in-vitro studies have shown that lumbrokinase supplements can decrease the presence of Hep B virus. One study in 2018 showed that lumbrokinase enzymes recognize and degrade HBeAg in vitro. An older study, in 2008, showed that lumbrokinase can decrease the level of Hep B and suppress its ability to spread.

Patients with Hep B Virus are more susceptible to hypercoagulation including:  deep vein thrombosis, pulmonary embolism, and myocardial infarction. Lumbrokinase supplements have been used since the dawn of Eastern Asian medicine, and studied since the early 1980s for use in hypercoagulation and resulting issues and diagnosis.

What is Lumbrokinase?

Traditional Eastern medicine in China, Japan, and Korea have used earthworm powder for thousands of years. According to the ancient Chinese medical textbook Compendium of Chinese Botanical and Animal Products (Ben Cao Gan Mu), earthworms are known as “Earth Dragons.” They possess the strength to invigorate blood, resolve status, and unblock the body’s "meridians and channels.”

In the modern age of science, researchers have identified which part of the earthworm influences blood viscosity (thickness of your blood).  In the 1980s, there was active research in Japan searching to isolate the exact substance in the earthworm that affects the blood.  Dr. Hisashi Mihara succeeded in finding the exact enzyme that affects blood thickness.  

What is Boluoke?

Boluoke is the brand name for the only patented and medically studied lumbrokinase enzyme supplement. All other competing lumbrokinase enzyme supplements are not a standardized lumbrokinase isolate, but rather a mixture of earthworm protein with some unmeasured lumbrokinase enzyme strength. 

Unfortunately, some companies are making products with 230 mg to 250mg of earthworm powder per capsule and then quote research that was conducted using Boluoke concentrated lumbrokinase enzymes. Boluoke capsules are 200mg in size and contain a verified 20mg of lumbrokinase inside each capsule. 

Lumbrokinase is an enzyme extracted from ground earthworm powder. I often get the question: Is Boluoke ground up earthworm powder? The answer is NO, it is an extract from an earthworm. A few hundred years ago, if you were trying to deal with blood issues, you likely would have ground up an earthworm and made it into a tea. But luckily, technology has isolated the exact enzymes and made taking lumbrokinase a lot easier, and less gross.  

What did I use it for?

I don’t have HepB, but I have used Boluoke with some remarkable resultsBoluoke is recommended for various conditions that include hypercoagulation as a symptom. This includes Lyme disease, CIRS Chronic Inflammatory Response Syndrome, DVT Deep Vein Thrombosis, Hepatitis B, blood clots, ischemic stroke, coronary artery disease, Alzheimer’s disease, and possibly long-haul Covid-19 Corona virus



Enzymes Protein molecules that create actions and reactions in your body
Lumbrokinase A fibrinolytic proteolytic enzyme found in earthworms
Boluoke A patented and standardized lumbrokinase supplement. It is also classified as a fibrinolytic, proteolytic, and systemic enzyme supplement.
Digestive Enzymes Enzymes made in the pancreas or taken as a supplement at the time you eat a meal

Proteolytic Enzymes

Enzymes that break down protein molecules; other examples of proteolytic enzymes are bromelain, serrapeptase and nattokinase.
Fibrinolytic enzymes A type of proteolytic enzyme that breaks down fibrin in your bloodstream. Boluoke is a fibrinolytic enzyme supplement. Nattokinase and serrapeptase are also fibrinolytic enzymes.
Systemic enzymes Enzymes that can affect the whole body including organs and tissues.


A review of enzymes


One of the first critical lessons I learned while working for Designs For Health, was the difference between a digestive enzyme supplement and a systemic enzyme supplement. If you take systemic enzyme supplements at the wrong time, you are wasting your time and money. Enzymes supplements were among the very first supplements (along with Omega 3 fish oil) that I ever used. 

Digestive enzymes do exactly what their name states: they aid in digesting your food. If you have Crohn’s disease, Pancreatic insufficiency (PI) or other digestive disorders, your pancreas may not be making enough enzymes to digest the food that you eat. 

Systemic enzyme supplements are intended to be taken on an empty stomach so that they can be absorbed and enter the bloodstream instead of being used during the digestion of food. 

Your body makes enzymes from proteins (amino acids) you eat in your diet.  Raw foods have enzymes; raw vegetables contain enough enzymes to digest that particular food. Raw vegetables don’t contain “extra” enzymes to store for later or use for digesting other foods. Any heated or processed food, including meat, does not have any living enzymes left. Luckily, our pancreases make enzymes for digesting the food we eat. If your pancreas doesn’t make enough digestive enzymes, you can take a supplement.  

What exactly are enzymes? 

Enzymes are found in all living cells. They speed up reactions in your body.  They are biological catalysts---that means they start processes within your body. 

An enzyme molecule has active sites that attach and create a process in a substrate. In other words, an enzyme creates an action or reaction for other molecules in your body. In the case of digestion, an enzyme breaks apart food molecules (substrate) so that your body can absorb individual nutrients. The enzyme may come from your pancreas or maybe a digestive enzyme supplement you take when you eat.  

 In the case of a biofilm, an enzyme (lumbrokinase) breaks apart the microbial cells (substrate) that create the biofilm. In the case of Alzheimer’s disease, a lumbrokinase enzyme may break down the insulin amyloid plaque that is seen in the brain. In the case of a blood cot, a fibrinolytic enzyme (Boluoke) will cleave apart the fibrin creating the clot. 

Enzymes are made in our bodies and can be taken as supplements. They always possess the power to start a reaction or process. Boluoke lumbrokinase enzyme supplement may be the most potent and versatile enzyme supplement you can take. With over 650 medical studies in Asia, lumbrokinase holds promise to help myriad conditions and symptoms. 

For a personalized protocol to introduce Boluoke into your healing regime, schedule a consult with me, Carly Neubert BA, NC.

Links to the research articles:

  1. An Earthworm Protease Cleaving Serum Fibronectin and Decreasing HBeAg in HepG2.2.15 Cells 
  2. Lumbrokinase Isozyme Targets Hepatitis B E-Antigen
  3. Lumbrokinase in a Potential Function to Intervene Chronic Hepatitis B
  4. Lumbrokinase article