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Supports Healthy Intestinal Microflora and GI Function • Probiotic Yeast Formula
This single ingredient Saccharomyces boulardii powder comes with a small, single scoop for measuring accuracy; this clean-label formulation is particularly effective and uniquely convenient for use in high-potency titration protocols. Saccharomyces boulardii is a non-pathogenic, transient yeast. Since its discovery in 1920, clinicians worldwide have used S. boulardii to support normal bowel transit time, promote healthy immune and inflammatory response, and bolster gastrointestinal microbiota diversity, particularly in conjunction with antibiotic therapy. S. boulardii is also commonly used to safely and effectively displace undesirable yeast species, which may play a beneficial role in neurological health, particularly for individuals on the neurodiverse spectrum.
Benefits and Features:
Ther-Biotic® Saccharomyces boulardii is also available in vegetarian capsules.
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Serving Size: 1 Scoop (1 mL or 600 mg) |
Amount/Serving |
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Saccharomyces boulardii |
9 billion CFU (Approx. 600 mg) |
Other Ingredients: None.
Made without of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, soybeans, and sesame. No synthetic colors, flavors, or preservatives. Vegan and non-GMO.
Adults: 1 scoop up to 5 times daily with water, juice, food, or as directed by a healthcare professional.
Children: As directed by a healthcare practitioner.
Caution: Not recommended for severely immunocompromised individuals or those with central venous catheters. Consult with your physician if you are pregnant or nursing, or have any medical condition, or taking prescription drugs, or under the age of 18 years. KEEP OUT OF REACH OF CHILDREN.
Saccharomyces boulardii is a nonpathogenic, transient yeast. Since its discovery in 1920, clinicians worldwide have used S. boulardii to support normal bowel transit time, promote healthy immune and inflammatory processes in the digestive tract, and bolster gastrointestinal microbiota diversity, particularly in conjunction with antibiotic therapy. S. boulardii is also commonly used to safely and effectively displace undesirable yeast species.
Mechanisms of Action:
S. boulardii has a long track record of demonstrated efficacy in both animal experiments and human clinical trials to support gastrointestinal health. As recently as 2016, the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition based their recommendation for use of S. boulardii on its quality of evidence.
In 2014, a pooled data review of 22 qualifying studies concluded that S. boulardii is a safe and effective approach to reducing the frequency and duration of occasional diarrhea. A more recent 2016 review suggests S. boulardii may promote these positive outcomes by acting directly on non-beneficial species or their toxins and by supporting host immune signaling cascades and innate and adaptive immune system responses.
In an additional 2015 meta-analysis of 11 randomized, controlled trials involving 2,200 subjects (including 330 children), administration of S. boulardii during triple therapy for a non-beneficial bacterium resulted in significantly improved outcomes and decreased adverse effects compared to controls.
Use of S. boulardii to effectively compete with undesirable yeast species is also a common practice, based on its ability to inhibit adhesion and influence inflammatory response as demonstrated in in vitro studies by Murzyn and colleagues.
In addition to promoting beneficial bacteria and yeast in the digestive tract, S. boulardii supplementation also has pronounced effects on digestive enzymes of the brush border membrane and has been demonstrated to enhance nutrient acquisition for the host.
Does Saccharomyces boulardii colonize the intestinal tract?
S. boulardii does not colonize the human intestinal tract and is not one of the microorganisms that normally inhabit the intestines. It is a transient yeast that passes through the intestines after ingestion. S. boulardii does not attach to the mucosal cells lining the intestines, but exerts its beneficial effects on the host as it moves through the gastrointestinal tract.
Is Saccharomyces boulardii the same as Saccharomyces cerevisiae?
No, S. boulardii is not S. cerevisiae. S. boulardii is a wild, tropical yeast while S. cerevisiae is commonly known as brewer’s or baker’s yeast. Closely related to S. cerevisiae, S. boulardii is officially classified as Saccharomyces cerevisiae var boulardii Hansen CBS 5926. The 2 species have different genetic makeup and enzyme profiles. Unlike S. cerevisiae, S. boulardii does not make a certain type of reproductive spore called an ascospore and does not use the sugar galactose. It is very resistant to heat and acid and secretes a number of unique physiologically active factors. Only S. boulardii has proven gastrointestinal supportive effects.
What are the primary uses for Saccharomyces boulardii?
S. boulardii has been used to positively affect gastrointestinal function in the following situations:
