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NuMedica's New Perspectives for Age-Old Problems

by Carly Neubert, BA, NC on February 01, 2023

NuMedica has consistently been a top-performer for results and value. From their variety, to their top-notch quality, it’s no wonder we see great results and reviews exceeding our own expectations month after month. NuMedica has been the topic of discussion in our blogs over the years. If you’re curious about NuMedica, here is a whole list of blogs you can binge-read this weekend:


    This blog in particular will focus more on two products: NeuroMethylation Cream and Joint Replete. 

    NeuroMethylation Cream

    First, we have NeuroMethylation Cream. It is composed of five nutrients that support the methylation process for immune and neurological function. 

    Before I go further, what is the methylation process? This process occurs when a molecule called a “methyl group” is added to DNA, proteins, or other molecules. When the methyl groups are added, it can affect the way that the molecule acts in the body. For example, when looking at the immune system, methylation can affect the activation (or lack of activation) of immune cells

    The five essential nutrients in NeuroMethylation Cream include:

    5-MTHF (5-methyltetrahydrofolate)

    5-MTHF is an alternative to taking folic acid supplements. Folic acid supplements can take time to be converted to 5-MTHF in the body. 5-MTHF is very well absorbed in the body. Your body can more readily use this form instead of converting it from whole foods or folic acid supplements.


    This is a form of Vitamin B12 that is highly bioavailable (easily absorbed in your body). Vitamin B12 is important because your body needs it to make red blood cells. 


    This is another form of Vitamin B12 that is important in maintaining a healthy nervous system. A 2015 study concluded that the implementation of this B12 form could provide support in treating neuropathic pain. 

    Pyridoxal-5’- Phosphate

    This is a form of Vitamin B6 - an important part of brain development and keeping your immune system and nervous system healthy. Since your body cannot produce Vitamin B6, you have to get adequate amounts from your diet and supplementation. 

    Natural Vitamin D3

    I’ve written about the importance of vitamin D in previous blog posts. Vitamin D3 helps your body absorb calcium - which can impact the strength of your bones. Your immune system can also experience a boost

    Reviews for NeuroMethylation Cream

    Paula L. purchased the NeuroMethylation Cream and said:

    “Helps me get vital nutrients and vitamins that I don't tolerate internally. This is applied topically, bypasses the gut, and absorbs through the skin. I am glad that my practitioner introduced me to it!”

    Lynne F. purchased the NeuroMethylation Cream and said:

    “This product is really helping me. It is easy to use and has a pleasant smell. I tried taking folic acid pills and they made me sick. This does not.”

    Natasha L. purchased the NeuroMethylation Cream and said:

    “I have been using this product for several years and I can feel the difference it makes. Highly recommend!”

    FAQs on NeuroMethylation Cream

    How does methylation affect health?

    Methylation means adding methyl groups to molecules already present in your body.  It happens about a billion times per second and it affects all aspects of your health by turning off or turning on genes and their expression. 

    What are the symptoms of poor methylation?

    Signs of poor methylation or under-methylation can be complicated.  Just about any symptom you have can be related to methylation.  Everything from mental illness to cancer can be caused by methylation status.  It is important to check your genetics for any SNPs in the genes that support methylation.  The most common gene to analyze is MTHFR.  Genetics tests are easily purchased through 23andMe or other at-home testing companies. 

    What foods increase methylation?

    Some superfoods for methylation include dark leafy greens, beets, and mushrooms. This is because of the higher content of folate and B vitamins. 


    Joint Replete: Another Potent Formula

    Joint Replete was designed as a joint and soft tissue formula. The star of the show is ETArol. This ingredient is a high quality green-lipped mussel extract straight from New Zealand. This is a premium and well-researched nutrient for joints and tissues. 

    The ingredients in this formula include:

    Green lipped mussel extract

    Green-lipped mussel extract has been studied for its effectiveness in addressing joint pain, stiffness, and mobility. The mussel extract contains anti-inflammatory properties as well as other nutrients including B vitamins.


    Also known as MSM, this supplement has been commonly used for addressing joint pain as well as muscle recovery after stress/damage.

    Chondroitin Sulfate

    Chondroitin sulfate is a compound that is an important part of making up the tissue that cushions joints. It is primarily taken to manage osteoarthritis. A 2018 review concluded that the usage of Chondroitin supplements may improve joint pain and overall function. 

    Glucosamine Sulfate

    Glucosamine is a compound found in cartilage. Cartilage is the tough tissue that cushions joints. Derived from the shells of shellfish, glucosamine sulfate has been the center of osteoarthristis studies as of late. Different formulations of glucosamine can have different structural benefits for joints. 

    Hyaluronic Acid

    Hyaluronic Acid has been a useful tool in treating osteoarthritis symptoms and pain. It is naturally found in the fluid surrounding joints. It acts as a lubricant for movement. It has become a trending ingredient in skincare lately, but it poses some great potential benefits for addressing joint mobility and pain as well. 

    Reviews for Joint Replete

    Sylvie K. purchased Joint Replete and said:

    “Tried many other supplements. This one hits the mark.”

    FAQs on Joint Replete

    What are green-lipped mussels?

    Green-lipped mussels are native to New Zealand and have a green shell. NuMedica’s formula utilizes the highest quality green-lipped mussel extract - ETArol.

    Is soft tissue damage serious?

    Soft tissue damage can be very hard to diagnose especially if you are using a traditional orthopedic doctor.  While orthopedic doctors specialize in joint movement and structure, physiatrists concentrate on soft tissue injury.  Soft tissue damage can result in chronic pain syndrome and misalignments of joints and bones. 

    Why is it called soft tissue?

    Soft tissue is referred to as such because it has not gone through the ossification/calcification processes that bones and teeth go through to be hard tissue. Soft tissue can include muscles, ligaments, connective tissue, or tendons. 

    What are soft tissue injuries?

    The top three soft tissue injuries are sprains, strains and contusions.   Low back pain which 84% of adults suffer with, can be caused by herniated discs or sacroiliac joint dysfunction.  Both of these problems are soft tissue injuries. 

    Concluding Thoughts

    NuMedica has such a variety of research-backed solutions - I could have an entire section of this blog dedicated to their different formulas and I wouldn’t run out of nutrients to talk about for a while. NuMedica has established itself as a reliable and reputable company, and we are proud to be an authorized retailer for them. Do you have any questions about your soft tissues and how they could be impacted by Joint Replete? Or, maybe you’re looking for ways to impact your body’s methylation processes. Don’t hesitate to reach out - Schedule a consult with me, Carly Neubert BA, NC.